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A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population.

Publication ,  Journal Article
Hu, Z; Miao, X; Ma, H; Wang, X; Tan, W; Wei, Q; Lin, D; Shen, H
Published in: Lung Cancer
April 2005

Cyclooxygenases (COXs) are key enzymes that convert arachidonic acid to prostaglandins. Overexpression of COX-2, one of the COX isozymes, has been shown to be an early event in lung carcinogenesis and may play an important role in lung cancer development. A common single nucleotide polymorphism, T8473C, located within a potential functional region in the 3'UTR of COX-2 gene was identified and we hypothesized that this COX-2 variant is associated with lung cancer risk. To test this hypothesis, we genotyped this variant in a case-control study of 322 histologically-confirmed lung cancer patients and 323 age and sex frequency-matched cancer-free controls in a Chinese population. The results showed that the frequencies of variant genotypes 8473CT/CC were significantly less common in the cases (27.3%) than in the controls (35.3%) (P=0.034), suggesting that the 8473C allele was protective against lung cancer. Multivariate logistic regression analyses revealed that the COX-2 variant genotypes (8473CT/CC) were associated with a significantly decreased risk of lung cancer compared with the 8473TT wild-type homozygotes (OR=0.64, 95% CI=0.45-0.92). When we defined the reference group as non-smokers having the 8473CT/CC variant genotypes, the smokers with the 8473TT wild-type genotype had the greatest risk (adjusted OR=5.28, 95% CI=3.10-9.00). These findings indicate that the COX-2 T8473C polymorphism may contribute to lung cancer susceptibility in the Chinese population. Further larger molecular epidemiological studies are warranted to confirm these findings.

Duke Scholars

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Published In

Lung Cancer

DOI

ISSN

0169-5002

Publication Date

April 2005

Volume

48

Issue

1

Start / End Page

11 / 17

Location

Ireland

Related Subject Headings

  • Risk Factors
  • Prostaglandin-Endoperoxide Synthases
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Middle Aged
  • Membrane Proteins
  • Male
  • Lung Neoplasms
  • Humans
 

Citation

APA
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Hu, Z., Miao, X., Ma, H., Wang, X., Tan, W., Wei, Q., … Shen, H. (2005). A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population. Lung Cancer, 48(1), 11–17. https://doi.org/10.1016/j.lungcan.2004.09.004
Hu, Z., X. Miao, H. Ma, X. Wang, W. Tan, Q. Wei, D. Lin, and H. Shen. “A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population.Lung Cancer 48, no. 1 (April 2005): 11–17. https://doi.org/10.1016/j.lungcan.2004.09.004.
Hu, Z., et al. “A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population.Lung Cancer, vol. 48, no. 1, Apr. 2005, pp. 11–17. Pubmed, doi:10.1016/j.lungcan.2004.09.004.
Hu Z, Miao X, Ma H, Wang X, Tan W, Wei Q, Lin D, Shen H. A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population. Lung Cancer. 2005 Apr;48(1):11–17.

Published In

Lung Cancer

DOI

ISSN

0169-5002

Publication Date

April 2005

Volume

48

Issue

1

Start / End Page

11 / 17

Location

Ireland

Related Subject Headings

  • Risk Factors
  • Prostaglandin-Endoperoxide Synthases
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Middle Aged
  • Membrane Proteins
  • Male
  • Lung Neoplasms
  • Humans