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A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer.

Publication ,  Journal Article
Xiong, P; Zheng, R; Wang, L-E; Bondy, ML; Shen, H; Borer, MM; Wei, Q; Sturgis, EM
Published in: Thyroid
February 2005

In vitro gamma-radiation-induced chromatid breaks per cell (b/c) in lymphocytes may be associated with risk of papillary thyroid cancer (PTC). This pilot case-control study involved 106 patients with thyroid disease (57 with PTC and 49 with benign thyroid disease) and 105 cancer-free matched controls. Multivariate logistic regression analyses identified that an elevated gamma-radiation-induced b/c value was a risk factor for PTC (adjusted odds ratio = 4.54; 95% CI, 2.07-9.95), and a dose-response relationship was evident when the b/c values were categorized into tertiles. High levels of chromatid breaks induced by gamma-radiation may constitute an independent risk factor for PTC, but further study is needed.

Duke Scholars

Published In

Thyroid

DOI

ISSN

1050-7256

Publication Date

February 2005

Volume

15

Issue

2

Start / End Page

94 / 99

Location

United States

Related Subject Headings

  • Thyroid Neoplasms
  • Thyroid Diseases
  • Risk Factors
  • Pilot Projects
  • Neoplasms, Radiation-Induced
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
 

Citation

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ICMJE
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Xiong, P., Zheng, R., Wang, L.-E., Bondy, M. L., Shen, H., Borer, M. M., … Sturgis, E. M. (2005). A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer. Thyroid, 15(2), 94–99. https://doi.org/10.1089/thy.2005.15.94
Xiong, Ping, Rong Zheng, Li-E Wang, Melissa L. Bondy, Hongbing Shen, Mary M. Borer, Qingyi Wei, and Erich M. Sturgis. “A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer.Thyroid 15, no. 2 (February 2005): 94–99. https://doi.org/10.1089/thy.2005.15.94.
Xiong P, Zheng R, Wang L-E, Bondy ML, Shen H, Borer MM, et al. A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer. Thyroid. 2005 Feb;15(2):94–9.
Xiong, Ping, et al. “A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer.Thyroid, vol. 15, no. 2, Feb. 2005, pp. 94–99. Pubmed, doi:10.1089/thy.2005.15.94.
Xiong P, Zheng R, Wang L-E, Bondy ML, Shen H, Borer MM, Wei Q, Sturgis EM. A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer. Thyroid. 2005 Feb;15(2):94–99.
Journal cover image

Published In

Thyroid

DOI

ISSN

1050-7256

Publication Date

February 2005

Volume

15

Issue

2

Start / End Page

94 / 99

Location

United States

Related Subject Headings

  • Thyroid Neoplasms
  • Thyroid Diseases
  • Risk Factors
  • Pilot Projects
  • Neoplasms, Radiation-Induced
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Logistic Models
  • Humans