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In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis.

Publication ,  Journal Article
Wang, L-E; Xiong, P; Strom, SS; Goldberg, LH; Lee, JE; Ross, MI; Mansfield, PF; Gershenwald, JE; Prieto, VG; Cormier, JN; Duvic, M; Weber, RS ...
Published in: J Natl Cancer Inst
December 21, 2005

BACKGROUND: Mutagen sensitivity, measured as mutagen-induced chromatid breaks per cell in primary lymphocytes in vitro, has been used to study susceptibility to various epithelial cancers. Patients with xeroderma pigmentosum are highly sensitive to ultraviolet (UV) light due to inherited defects in DNA repair and have a 1000-fold higher risk of UV-induced skin cancer than the general population. However, an association between UV-induced chromosomal aberrations and risk of skin cancer in the general population has not been established. METHODS: We assessed in vitro UVB-induced chromatid breaks in a hospital-based case-control study. The study included 469 patients with skin cancer (231 with nonmelanoma skin cancer [NMSC] and 238 with cutaneous malignant melanoma [CMM]) and 329 cancer-free control subjects. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). All statistical tests were two-sided. RESULTS: Compared with the frequency of UVB-induced chromatid breaks per cell in control subjects (mean = 0.28 breaks per cell, 95% CI = 0.27 to 0.30), that in NMSC patients (basal cell carcinoma [BCC], n = 143, mean = 0.36 breaks per cell, 95% CI = 0.33 to 0.39 and squamous cell carcinoma [SCC], n = 88, mean = 0.35 breaks per cell, 95% CI = 0.32 to 0.38) was higher (P = .001 and P < .001, respectively), but that in CMM case patients (mean = 0.30 breaks per cell, 95% CI = 0.28 to 0.33) was not (P = .22). A frequency of chromatid breaks per cell above the median of control subjects was associated with nearly threefold increased risks for BCC (OR = 2.78, 95% CI = 1.79 to 4.30) and SCC (OR = 2.62, 95% CI = 1.50 to 4.60), but not with an increased risk of CMM. A dose-response relationship was evident between mutagen sensitivity and risk for both BCC (Ptrend < .001) and SCC (Ptrend < .001). Multiplicative interactions between mutagen sensitivity and sun exposure variables on risk, particularly for sunburn in BCC and hair color, tanning ability, and family history of skin cancer in SCC, were seen for NMSC but not CMM. CONCLUSIONS: UVB-induced mutagen sensitivity may play a role in susceptibility to NMSC but not to CMM.

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Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

December 21, 2005

Volume

97

Issue

24

Start / End Page

1822 / 1831

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Sunburn
  • Skin Neoplasms
  • Skin
  • Risk Factors
  • Risk Assessment
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Mutation
  • Multivariate Analysis
 

Citation

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ICMJE
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Wang, L.-E., Xiong, P., Strom, S. S., Goldberg, L. H., Lee, J. E., Ross, M. I., … Wei, Q. (2005). In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis. J Natl Cancer Inst, 97(24), 1822–1831. https://doi.org/10.1093/jnci/dji429
Wang, Li-E, Ping Xiong, Sara S. Strom, Leonard H. Goldberg, Jeffrey E. Lee, Merrick I. Ross, Paul F. Mansfield, et al. “In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis.J Natl Cancer Inst 97, no. 24 (December 21, 2005): 1822–31. https://doi.org/10.1093/jnci/dji429.
Wang L-E, Xiong P, Strom SS, Goldberg LH, Lee JE, Ross MI, et al. In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis. J Natl Cancer Inst. 2005 Dec 21;97(24):1822–31.
Wang, Li-E., et al. “In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis.J Natl Cancer Inst, vol. 97, no. 24, Dec. 2005, pp. 1822–31. Pubmed, doi:10.1093/jnci/dji429.
Wang L-E, Xiong P, Strom SS, Goldberg LH, Lee JE, Ross MI, Mansfield PF, Gershenwald JE, Prieto VG, Cormier JN, Duvic M, Clayman GL, Weber RS, Lippman SM, Amos CI, Spitz MR, Wei Q. In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis. J Natl Cancer Inst. 2005 Dec 21;97(24):1822–1831.
Journal cover image

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

December 21, 2005

Volume

97

Issue

24

Start / End Page

1822 / 1831

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Sunburn
  • Skin Neoplasms
  • Skin
  • Risk Factors
  • Risk Assessment
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Mutation
  • Multivariate Analysis