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Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis.

Publication ,  Journal Article
Shi, Q; Zhang, Z; Li, G; Pillow, PC; Hernandez, LM; Spitz, MR; Wei, Q
Published in: Pharmacogenet Genomics
August 2005

Although tobacco is the major lung cancer risk factor, folate deficiency has also been implicated as a risk. Methionine synthase (MS; gene symbol, MTR) and methionine synthase reductase (MSR; gene symbol, MTRR) play important roles in the folate metabolism pathway. It was hypothesized that polymorphisms of MTR and MTRR are associated with lung cancer risk and interact with dietary intake of folate-related nutrients in lung cancer etiology. In a hospital-based, case-control study of 1,035 lung cancer cases and 1,148 controls of non-Hispanic whites, frequency matched by age, sex, ethnicity and smoking status, the MTR 2756A>G and MTRR 66A>G polymorphisms were genotyped. It was found that the MTRRG allele was associated with a significantly increased lung cancer risk [adjusted odd ratio (OR)=1.34, 95% confidence interval (CI)=1.06-1.70 for the AG genotype and OR=1.39, 95% CI=1.08-1.78 for the GG genotype compared to the AA genotype]. Further analysis suggested some evidence of gene-diet interactions between the MTRR 66A>G polymorphism and dietary intake of total folate and vitamin B12. When the two polymorphisms were evaluated together by the number of the variant alleles (i.e. the MTR2756G and MTRR66A), lung cancer risk was significantly increased in a dose-dependent manner (Ptrend=0.045). The risk of lung cancer was 1.29 (0.98-1.69) for one variant allele, and 1.36 (1.04-1.77) for two or more variant alleles compared to the wild-type (0 variant allele) genotype. In conclusion, our data provide evidence supporting the association between the MTR 2756A>G and MTRR 66A>G polymorphisms and lung cancer risk, which may be modulated by dietary nutrient intake.

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Published In

Pharmacogenet Genomics

DOI

ISSN

1744-6872

Publication Date

August 2005

Volume

15

Issue

8

Start / End Page

547 / 555

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Pharmacology & Pharmacy
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Ferredoxin-NADP Reductase
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shi, Q., Zhang, Z., Li, G., Pillow, P. C., Hernandez, L. M., Spitz, M. R., & Wei, Q. (2005). Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis. Pharmacogenet Genomics, 15(8), 547–555. https://doi.org/10.1097/01.fpc.0000170916.96650.70
Shi, Qiuling, Zhengdong Zhang, Guojun Li, Patricia C. Pillow, Ladia M. Hernandez, Margaret R. Spitz, and Qingyi Wei. “Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis.Pharmacogenet Genomics 15, no. 8 (August 2005): 547–55. https://doi.org/10.1097/01.fpc.0000170916.96650.70.
Shi Q, Zhang Z, Li G, Pillow PC, Hernandez LM, Spitz MR, et al. Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis. Pharmacogenet Genomics. 2005 Aug;15(8):547–55.
Shi, Qiuling, et al. “Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis.Pharmacogenet Genomics, vol. 15, no. 8, Aug. 2005, pp. 547–55. Pubmed, doi:10.1097/01.fpc.0000170916.96650.70.
Shi Q, Zhang Z, Li G, Pillow PC, Hernandez LM, Spitz MR, Wei Q. Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis. Pharmacogenet Genomics. 2005 Aug;15(8):547–555.

Published In

Pharmacogenet Genomics

DOI

ISSN

1744-6872

Publication Date

August 2005

Volume

15

Issue

8

Start / End Page

547 / 555

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Pharmacology & Pharmacy
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Ferredoxin-NADP Reductase
  • Female