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Gamma radiation-induced apoptosis, G2 delay, and the risk of salivary and thyroid carcinomas--a preliminary report.

Publication ,  Journal Article
Zheng, R; Dahlstrom, KR; Wei, Q; Sturgis, EM
Published in: Head Neck
July 2004

BACKGROUND: While radiation has been the only well-established risk factor for salivary and thyroid cancers, the exact mechanisms remain unknown. We hypothesized that individuals with altered apoptotic response to gamma irradiation may be susceptible to salivary and thyroid cancers. METHODS: We tested our hypothesis in a pilot case-control study of 29 patients with neoplasms of the salivary and thyroid glands and 29 cancer-free control subjects. Patients and control subjects were matched on age, sex, and ethnicity. In vitro gamma radiation-induced apoptosis in lymphocytes was quantified utilizing the TUNEL assay and flow cytometry. RESULTS: The mean apoptotic capacity was 13.55 +/- 10.54 for control subjects, 5.75 +/- 4.96 for patients with salivary gland carcinomas (p =.003), and 6.87 +/- 4.45 for patients with thyroid carcinomas (p =.006). These differences were associated with a 10-fold increased risk of salivary gland carcinoma (odds ratio [OR] = 10.71; 95% confidence interval [CI], 1.21-94.86) and a four-fold increased risk of thyroid carcinoma (OR = 3.93; 95% CI, 0.90-17.08). CONCLUSIONS: Our data suggests that gamma radiation-induced apoptosis may serve as a biomarker of genetic susceptibility to salivary and thyroid carcinoma, and further confirmatory studies with larger sample size are warranted.

Duke Scholars

Published In

Head Neck

DOI

ISSN

1043-3074

Publication Date

July 2004

Volume

26

Issue

7

Start / End Page

612 / 618

Location

United States

Related Subject Headings

  • Thyroid Neoplasms
  • Salivary Gland Neoplasms
  • Risk Factors
  • Otorhinolaryngology
  • Middle Aged
  • Male
  • Lymphocytes
  • In Situ Nick-End Labeling
  • Humans
  • Genetic Predisposition to Disease
 

Citation

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Zheng, R., Dahlstrom, K. R., Wei, Q., & Sturgis, E. M. (2004). Gamma radiation-induced apoptosis, G2 delay, and the risk of salivary and thyroid carcinomas--a preliminary report. Head Neck, 26(7), 612–618. https://doi.org/10.1002/hed.20053
Zheng, Rong, Kristina R. Dahlstrom, Qingyi Wei, and Erich M. Sturgis. “Gamma radiation-induced apoptosis, G2 delay, and the risk of salivary and thyroid carcinomas--a preliminary report.Head Neck 26, no. 7 (July 2004): 612–18. https://doi.org/10.1002/hed.20053.
Zheng R, Dahlstrom KR, Wei Q, Sturgis EM. Gamma radiation-induced apoptosis, G2 delay, and the risk of salivary and thyroid carcinomas--a preliminary report. Head Neck. 2004 Jul;26(7):612–8.
Zheng, Rong, et al. “Gamma radiation-induced apoptosis, G2 delay, and the risk of salivary and thyroid carcinomas--a preliminary report.Head Neck, vol. 26, no. 7, July 2004, pp. 612–18. Pubmed, doi:10.1002/hed.20053.
Zheng R, Dahlstrom KR, Wei Q, Sturgis EM. Gamma radiation-induced apoptosis, G2 delay, and the risk of salivary and thyroid carcinomas--a preliminary report. Head Neck. 2004 Jul;26(7):612–618.

Published In

Head Neck

DOI

ISSN

1043-3074

Publication Date

July 2004

Volume

26

Issue

7

Start / End Page

612 / 618

Location

United States

Related Subject Headings

  • Thyroid Neoplasms
  • Salivary Gland Neoplasms
  • Risk Factors
  • Otorhinolaryngology
  • Middle Aged
  • Male
  • Lymphocytes
  • In Situ Nick-End Labeling
  • Humans
  • Genetic Predisposition to Disease