Genomic instability and endoreduplication triggered by RAD17 deletion.
Publication
, Journal Article
Wang, X; Zou, L; Zheng, H; Wei, Q; Elledge, SJ; Li, L
Published in: Genes Dev
April 15, 2003
Cell cycle checkpoints are critical for genomic stability. Rad17, a component of the checkpoint clamp loader complex (Rad17/Rfc2-5), is required for the response to DNA damage and replication stress. To explore the role of Rad17 in the maintenance of genomic integrity, we established somatic conditional alleles of RAD17 in human cells. We find that RAD17 is not only important for the Atr-mediated checkpoint but is also essential for cell viability. Cells lacking RAD17 exhibited acute chromosomal aberrations and underwent endoreduplication at a high rate. Therefore, RAD17 links the checkpoint to ploidy control and is essential for the maintenance of chromosomal stability.
Duke Scholars
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Published In
Genes Dev
DOI
ISSN
0890-9369
Publication Date
April 15, 2003
Volume
17
Issue
8
Start / End Page
965 / 970
Location
United States
Related Subject Headings
- Viral Proteins
- Transfection
- Phosphorylation
- Phosphoproteins
- Karyotyping
- Integrases
- Humans
- Gene Duplication
- Gene Deletion
- Exodeoxyribonucleases
Citation
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Chicago
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Wang, X., Zou, L., Zheng, H., Wei, Q., Elledge, S. J., & Li, L. (2003). Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev, 17(8), 965–970. https://doi.org/10.1101/gad.1065103
Wang, Xin, Lee Zou, Huyong Zheng, Qingyi Wei, Stephen J. Elledge, and Lei Li. “Genomic instability and endoreduplication triggered by RAD17 deletion.” Genes Dev 17, no. 8 (April 15, 2003): 965–70. https://doi.org/10.1101/gad.1065103.
Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L. Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev. 2003 Apr 15;17(8):965–70.
Wang, Xin, et al. “Genomic instability and endoreduplication triggered by RAD17 deletion.” Genes Dev, vol. 17, no. 8, Apr. 2003, pp. 965–70. Pubmed, doi:10.1101/gad.1065103.
Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L. Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev. 2003 Apr 15;17(8):965–970.
Published In
Genes Dev
DOI
ISSN
0890-9369
Publication Date
April 15, 2003
Volume
17
Issue
8
Start / End Page
965 / 970
Location
United States
Related Subject Headings
- Viral Proteins
- Transfection
- Phosphorylation
- Phosphoproteins
- Karyotyping
- Integrases
- Humans
- Gene Duplication
- Gene Deletion
- Exodeoxyribonucleases