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Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck.

Publication ,  Journal Article
Sturgis, EM; Castillo, EJ; Li, L; Zheng, R; Eicher, SA; Clayman, GL; Strom, SS; Spitz, MR; Wei, Q
Published in: Carcinogenesis
November 1999

Because reduced DNA repair capacity (phenotype) has been suggested as a risk factor for squamous cell carcinoma of the head and neck (SCCHN), newly-identified DNA repair gene polymorphisms (genotype) may also be implicated in risk. To test this hypothesis, we conducted a case-control study of 203 SCCHN patients and 424 control subjects (matched for age, sex and ethnicity) to investigate the role of two XRCC1 polymorphisms (XRCC1 26304 T and XRCC1 28152 A, respectively) in SCCHN. Multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (OR) and 95% confidence interval (CI). A total of 180 cases (88.7%) and 363 controls (85.6%) lacked the XRCC1 26304 T allele [adjusted OR = 1.34 (CI, 0.80-2.25)]. Lack of this polymorphism was a significant risk factor specifically for cancers of the oral cavity and pharynx [adjusted OR = 2.46 (CI, 1.22-4.97)]. Thirty-two cases (15.8%) and 46 controls (10.8%) were homozygous for the XRCC1 28152 A allele [adjusted OR = 1.59 (CI, 0.97-2.61) for all cases, and 1.41 (CI, 0. 80-2.48) for oral and pharyngeal cancer only]. Furthermore, when the two genotypes were combined into a three-level model of risk, a polymorphism-polymorphism interaction of increasing risk (trend test, P = 0.049) was evident: OR = 1.0 for those with neither risk genotype (referent group), adjusted OR = 1.51 (CI, 0.87-2.61) for those with either risk genotype, and 2.02 (CI, 1.00-4.05) for those with both risk genotypes. For oral and pharyngeal cancer, this trend was even more pronounced with the adjusted OR = 2.68 (CI, 1.28-5.61) for those with either risk genotype, and 3.22 (CI, 1.33-7.81) for those with both risk genotypes. The findings support the hypothesis that a polymorphic XRCC1 DNA repair gene contributes to risk of developing SCCHN.

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Published In

Carcinogenesis

DOI

ISSN

0143-3334

Publication Date

November 1999

Volume

20

Issue

11

Start / End Page

2125 / 2129

Location

England

Related Subject Headings

  • X-ray Repair Cross Complementing Protein 1
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Humans
  • Head and Neck Neoplasms
  • Genetic Predisposition to Disease
  • DNA-Binding Proteins
  • DNA Repair
  • DNA Primers
  • Carcinoma, Squamous Cell
 

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Sturgis, E. M., Castillo, E. J., Li, L., Zheng, R., Eicher, S. A., Clayman, G. L., … Wei, Q. (1999). Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck. Carcinogenesis, 20(11), 2125–2129. https://doi.org/10.1093/carcin/20.11.2125
Sturgis, E. M., E. J. Castillo, L. Li, R. Zheng, S. A. Eicher, G. L. Clayman, S. S. Strom, M. R. Spitz, and Q. Wei. “Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck.Carcinogenesis 20, no. 11 (November 1999): 2125–29. https://doi.org/10.1093/carcin/20.11.2125.
Sturgis EM, Castillo EJ, Li L, Zheng R, Eicher SA, Clayman GL, et al. Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck. Carcinogenesis. 1999 Nov;20(11):2125–9.
Sturgis, E. M., et al. “Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck.Carcinogenesis, vol. 20, no. 11, Nov. 1999, pp. 2125–29. Pubmed, doi:10.1093/carcin/20.11.2125.
Sturgis EM, Castillo EJ, Li L, Zheng R, Eicher SA, Clayman GL, Strom SS, Spitz MR, Wei Q. Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck. Carcinogenesis. 1999 Nov;20(11):2125–2129.

Published In

Carcinogenesis

DOI

ISSN

0143-3334

Publication Date

November 1999

Volume

20

Issue

11

Start / End Page

2125 / 2129

Location

England

Related Subject Headings

  • X-ray Repair Cross Complementing Protein 1
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Humans
  • Head and Neck Neoplasms
  • Genetic Predisposition to Disease
  • DNA-Binding Proteins
  • DNA Repair
  • DNA Primers
  • Carcinoma, Squamous Cell