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DNA repair and susceptibility to basal cell carcinoma: a case-control study.

Publication ,  Journal Article
Wei, Q; Matanoski, GM; Farmer, ER; Hedayati, MA; Grossman, L
Published in: Am J Epidemiol
October 1, 1994

This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free dermatologic controls who had had noncancerous skin disorders diagnosed between 1987 and 1990. Logistic regression models were used to assess the independent effect of the selected variables stratified by DNA repair level, with adjustment for age and family history. Skin type, lifetime number of severe sunburns, and actinic elastosis were also selected as risk factors for basal cell carcinoma. Cryopreserved lymphocytes from 88 cases and 135 controls were used for the DNA repair assay. When data were stratified by DNA repair level and adjusted for age and family history of skin cancer, significantly increased odds ratios associated with lighter skin (odds ratio (OR) = 3.2, 95% confidence interval (CI) 1.5-7.3), six or more severe sunburns in a lifetime (OR = 4.2, 95% CI 1.6-10.7), and moderate or severe actinic elastosis (OR = 4.4, 95% CI 1.5-12.8) were observed in persons with low DNA repair but not in those with high DNA repair. These findings suggest that impaired DNA repair may be a susceptibility factor for sunlight-induced skin cancer in the general public, as it is in patients with xeroderma pigmentosum.

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Published In

Am J Epidemiol

DOI

ISSN

0002-9262

Publication Date

October 1, 1994

Volume

140

Issue

7

Start / End Page

598 / 607

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Risk Factors
  • Middle Aged
  • Maryland
  • Male
  • Humans
  • Female
  • Epidemiology
  • Disease Susceptibility
  • DNA Repair
 

Citation

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Wei, Q., Matanoski, G. M., Farmer, E. R., Hedayati, M. A., & Grossman, L. (1994). DNA repair and susceptibility to basal cell carcinoma: a case-control study. Am J Epidemiol, 140(7), 598–607. https://doi.org/10.1093/oxfordjournals.aje.a117297
Wei, Q., G. M. Matanoski, E. R. Farmer, M. A. Hedayati, and L. Grossman. “DNA repair and susceptibility to basal cell carcinoma: a case-control study.Am J Epidemiol 140, no. 7 (October 1, 1994): 598–607. https://doi.org/10.1093/oxfordjournals.aje.a117297.
Wei Q, Matanoski GM, Farmer ER, Hedayati MA, Grossman L. DNA repair and susceptibility to basal cell carcinoma: a case-control study. Am J Epidemiol. 1994 Oct 1;140(7):598–607.
Wei, Q., et al. “DNA repair and susceptibility to basal cell carcinoma: a case-control study.Am J Epidemiol, vol. 140, no. 7, Oct. 1994, pp. 598–607. Pubmed, doi:10.1093/oxfordjournals.aje.a117297.
Wei Q, Matanoski GM, Farmer ER, Hedayati MA, Grossman L. DNA repair and susceptibility to basal cell carcinoma: a case-control study. Am J Epidemiol. 1994 Oct 1;140(7):598–607.
Journal cover image

Published In

Am J Epidemiol

DOI

ISSN

0002-9262

Publication Date

October 1, 1994

Volume

140

Issue

7

Start / End Page

598 / 607

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Risk Factors
  • Middle Aged
  • Maryland
  • Male
  • Humans
  • Female
  • Epidemiology
  • Disease Susceptibility
  • DNA Repair