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The use of a Type-I lyophilisate collagen as an osteoinductive factor in pseudarthroses of the forearm.

Publication ,  Journal Article
Strassmair, M; Mont, MA; Seyler, TM; Bosebeck, H; Marker, DR; LaPorte, DM
Published in: Surg Technol Int
April 2009

The purpose of this study was to assess the use of a novel bone void filler consisting of Type I collagen and various growth factors (VEGF, TGFβ-1, TGFβ-2, IGF-1, BMP-2, BMP-3, and BMP-7) and surgical fixation to treat diaphyseal forearm pseudarthroses. Eleven patients underwent an osteosynthesis procedure for isolated pseudarthrosis fractures of the forearm (six radial and five ulnar diaphysis). The mean duration between the initial failed surgical fixation and re-operation was 38 weeks. Radiographic signs of fracture healing after the application of the bone void filler were noted at a mean of 5 weeks, and complete fracture consolidation was achieved at a mean of 6 weeks. All patients demonstrated improved range of motion and grip strength. Additionally, all patients were pain-free by 6 weeks. The combination of a novel bovine bone-derived bone void filler and stable internal fixation led to union and rapid healing of forearm pseudarthroses.

Duke Scholars

Published In

Surg Technol Int

ISSN

1090-3941

Publication Date

April 2009

Volume

18

Start / End Page

213 / 218

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Pseudarthrosis
  • Osteogenesis
  • Middle Aged
  • Male
  • Intercellular Signaling Peptides and Proteins
  • Humans
  • Guided Tissue Regeneration
  • Freeze Drying
 

Citation

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Strassmair, M., Mont, M. A., Seyler, T. M., Bosebeck, H., Marker, D. R., & LaPorte, D. M. (2009). The use of a Type-I lyophilisate collagen as an osteoinductive factor in pseudarthroses of the forearm. Surg Technol Int, 18, 213–218.
Strassmair, M., M. A. Mont, T. M. Seyler, H. Bosebeck, D. R. Marker, and D. M. LaPorte. “The use of a Type-I lyophilisate collagen as an osteoinductive factor in pseudarthroses of the forearm.Surg Technol Int 18 (April 2009): 213–18.
Strassmair M, Mont MA, Seyler TM, Bosebeck H, Marker DR, LaPorte DM. The use of a Type-I lyophilisate collagen as an osteoinductive factor in pseudarthroses of the forearm. Surg Technol Int. 2009 Apr;18:213–8.
Strassmair, M., et al. “The use of a Type-I lyophilisate collagen as an osteoinductive factor in pseudarthroses of the forearm.Surg Technol Int, vol. 18, Apr. 2009, pp. 213–18.
Strassmair M, Mont MA, Seyler TM, Bosebeck H, Marker DR, LaPorte DM. The use of a Type-I lyophilisate collagen as an osteoinductive factor in pseudarthroses of the forearm. Surg Technol Int. 2009 Apr;18:213–218.

Published In

Surg Technol Int

ISSN

1090-3941

Publication Date

April 2009

Volume

18

Start / End Page

213 / 218

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Pseudarthrosis
  • Osteogenesis
  • Middle Aged
  • Male
  • Intercellular Signaling Peptides and Proteins
  • Humans
  • Guided Tissue Regeneration
  • Freeze Drying