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Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans.

Publication ,  Journal Article
Vaidya, VS; Waikar, SS; Ferguson, MA; Collings, FB; Sunderland, K; Gioules, C; Bradwin, G; Matsouaka, R; Betensky, RA; Curhan, GC; Bonventre, JV
Published in: Clin Transl Sci
December 2008

Acute kidney injury (AKI) is associated with high morbidity and mortality. The lack of sensitive and specific injury biomarkers has greatly impeded the development of therapeutic strategies to improve outcomes of AKI.The unique objective of this study was to evaluate the diagnostic performance of nine urinary biomarkers of AKI-kidney injury molecule-1 (KIM-1), neutrophil gelatinase associated lipocalin (NGAL), interleukin-18 (IL-18), hepatocyte growth factor (HGF), cystatin C (Cys), N-acetyl-beta-D-glucosaminidase (NAG), vascular endothelial growth factor (VEGF), chemokine interferon-inducible protein 10 (IP-10; CXCL10), and total protein-in a cross-sectional comparison of 204 patients with or without AKI.Median urinary concentrations of each biomarker were significantly higher in patients with AKI than in those without AKI (p < 0.001). The area under the receiver operating characteristics curve (AUC-ROC) for the combination of biomarkers using a logic regression model [risk score of 2.93*(NGAL > 5.72 and HGF > 0.17) + 2.93*(PROTEIN > 0.22) -2*(KIM < 0.58)] was greater (0.94) than individual biomarker AUC-ROCs. Age-adjusted levels of urinary KIM-1, NAG, HGF, VEGF, and total protein were significantly higher in patients who died or required renal replacement therapy (RRT) when compared to those who survived and did not require RRT.Our results demonstrate the comparative value of multiple biomarkers in the diagnosis and prognosis of AKI.

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Published In

Clin Transl Sci

DOI

EISSN

1752-8062

Publication Date

December 2008

Volume

1

Issue

3

Start / End Page

200 / 208

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Renal Replacement Therapy
  • ROC Curve
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • General Clinical Medicine
  • Female
  • Biomarkers
 

Citation

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Vaidya, V. S., Waikar, S. S., Ferguson, M. A., Collings, F. B., Sunderland, K., Gioules, C., … Bonventre, J. V. (2008). Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci, 1(3), 200–208. https://doi.org/10.1111/j.1752-8062.2008.00053.x
Vaidya, Vishal S., Sushrut S. Waikar, Michael A. Ferguson, Fitz B. Collings, Kelsey Sunderland, Costas Gioules, Gary Bradwin, et al. “Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans.Clin Transl Sci 1, no. 3 (December 2008): 200–208. https://doi.org/10.1111/j.1752-8062.2008.00053.x.
Vaidya VS, Waikar SS, Ferguson MA, Collings FB, Sunderland K, Gioules C, et al. Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci. 2008 Dec;1(3):200–8.
Vaidya, Vishal S., et al. “Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans.Clin Transl Sci, vol. 1, no. 3, Dec. 2008, pp. 200–08. Pubmed, doi:10.1111/j.1752-8062.2008.00053.x.
Vaidya VS, Waikar SS, Ferguson MA, Collings FB, Sunderland K, Gioules C, Bradwin G, Matsouaka R, Betensky RA, Curhan GC, Bonventre JV. Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci. 2008 Dec;1(3):200–208.
Journal cover image

Published In

Clin Transl Sci

DOI

EISSN

1752-8062

Publication Date

December 2008

Volume

1

Issue

3

Start / End Page

200 / 208

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Renal Replacement Therapy
  • ROC Curve
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • General Clinical Medicine
  • Female
  • Biomarkers