Scholars@Duke

A bio-inspired spatial patterning circuit.

Publication ,  Journal Article
Chen, K-Y; Joe, DJ; Shealy, JB; Land, BR; Shen, X
Published in: Annu Int Conf IEEE Eng Med Biol Soc
2014
Published version (DOI) Link to item

Lateral Inhibition (LI) is a widely conserved patterning mechanism in biological systems across species. Distinct from better-known Turing patterns, LI depend on cell-cell contact rather than diffusion. We built an in silico genetic circuit model to analyze the dynamic properties of LI. The model revealed that LI amplifies differences between neighboring cells to push them into opposite states, hence forming stable 2-D patterns. Inspired by this insight, we designed and implemented an electronic circuit that recapitulates LI patterning dynamics. This biomimetic system serve as a physical model to elucidate the design principle of generating robust patterning through spatial feedback, regardless of the underlying devices being biological or electrical.

Duke Scholars

Xiling Shen
Author Xiling Shen Pathology

Published In

Annu Int Conf IEEE Eng Med Biol Soc

DOI

10.1109/EMBC.2014.6943535

EISSN

2694-0604

Publication Date

2014

Volume

2014

Start / End Page

86 / 89

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Notch
  • Models, Biological
  • Computer Simulation
  • Cell Communication
  • Body Patterning
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
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Chen, K.-Y., Joe, D. J., Shealy, J. B., Land, B. R., & Shen, X. (2014). A bio-inspired spatial patterning circuit. Annu Int Conf IEEE Eng Med Biol Soc, 2014, 86–89. https://doi.org/10.1109/EMBC.2014.6943535
Chen, Kai-Yuan, Danial J. Joe, James B. Shealy, Bruce R. Land, and Xiling Shen. “A bio-inspired spatial patterning circuit.” Annu Int Conf IEEE Eng Med Biol Soc 2014 (2014): 86–89. https://doi.org/10.1109/EMBC.2014.6943535.
Chen K-Y, Joe DJ, Shealy JB, Land BR, Shen X. A bio-inspired spatial patterning circuit. Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:86–9.
Chen, Kai-Yuan, et al. “A bio-inspired spatial patterning circuit.” Annu Int Conf IEEE Eng Med Biol Soc, vol. 2014, 2014, pp. 86–89. Pubmed, doi:10.1109/EMBC.2014.6943535.
Chen K-Y, Joe DJ, Shealy JB, Land BR, Shen X. A bio-inspired spatial patterning circuit. Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:86–89.

Published In

Annu Int Conf IEEE Eng Med Biol Soc

DOI

10.1109/EMBC.2014.6943535

EISSN

2694-0604

Publication Date

2014

Volume

2014

Start / End Page

86 / 89

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Notch
  • Models, Biological
  • Computer Simulation
  • Cell Communication
  • Body Patterning
  • Animals