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Retinal Vein Occlusion in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Disease Study.

Publication ,  Journal Article
Koh, V; Cheung, CY; Li, X; Tian, D; Wang, JJ; Mitchell, P; Cheng, C-Y; Wong, TY
Published in: Ophthalmic Epidemiol
2016

PURPOSE: To describe the prevalence of retinal vein occlusion (RVO) and its risk factors in a multi-ethnic Asian population. METHODS: This population-based study of 10,033 participants (75.7% response rate) included Chinese, Indian and Malay persons aged 40 years and older. A comprehensive ophthalmic examination, standardized interviews and laboratory blood tests were performed. Digital fundus photographs were assessed for presence of RVO following the definitions used in the Blue Mountains Eye Study. Regression analysis models were constructed to study the relationship between ocular and systemic factors and RVO. Age-specific prevalence rates of RVO were applied to project the number of people affected in Asia from 2013 to 2040. RESULTS: The overall crude prevalence of RVO was 0.72% (n = 71; 95% confidence interval, CI, 0.54-0.87%). The crude prevalence of RVO was similar in Chinese, Indian and Malay participants (p = 0.865). In multivariable regression models, significant risk factors of RVO included increased age (odds ratio, OR, 1.03, 95% CI 1.01-1.06), hypertension (OR 3.65, 95% CI 1.61-8.31), increased serum creatinine (OR 1.04, 95% CI 1.01-1.06, per 10 mmol/L increase), history of heart attack (OR 2.25, 95% CI 1.11-4.54) and increased total cholesterol (OR 1.31, 95% CI 1.07-1.59, per 1 mmol/L increase). None of the ocular parameters were associated with RVO. RVO is estimated to affect up to 16 and 21 million people in Asia by 2020 and 2040, respectively. CONCLUSION: RVO was detected in 0.72% of a multi-ethnic Asian population aged 40-80 years in Singapore. The significant systemic risk factors of RVO are consistent with studies in white populations.

Duke Scholars

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Published In

Ophthalmic Epidemiol

DOI

EISSN

1744-5086

Publication Date

2016

Volume

23

Issue

1

Start / End Page

6 / 13

Location

England

Related Subject Headings

  • Visual Acuity
  • Singapore
  • Risk Factors
  • Retinal Vein Occlusion
  • Prevalence
  • Middle Aged
  • Male
  • Humans
  • Female
  • Ethnicity
 

Citation

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Chicago
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MLA
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Koh, V., Cheung, C. Y., Li, X., Tian, D., Wang, J. J., Mitchell, P., … Wong, T. Y. (2016). Retinal Vein Occlusion in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Disease Study. Ophthalmic Epidemiol, 23(1), 6–13. https://doi.org/10.3109/09286586.2015.1082604
Koh, Victor, Carol Y. Cheung, Xiang Li, Dechao Tian, Jie Jin Wang, Paul Mitchell, Ching-Yu Cheng, and Tien Y. Wong. “Retinal Vein Occlusion in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Disease Study.Ophthalmic Epidemiol 23, no. 1 (2016): 6–13. https://doi.org/10.3109/09286586.2015.1082604.
Koh V, Cheung CY, Li X, Tian D, Wang JJ, Mitchell P, et al. Retinal Vein Occlusion in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Disease Study. Ophthalmic Epidemiol. 2016;23(1):6–13.
Koh, Victor, et al. “Retinal Vein Occlusion in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Disease Study.Ophthalmic Epidemiol, vol. 23, no. 1, 2016, pp. 6–13. Pubmed, doi:10.3109/09286586.2015.1082604.
Koh V, Cheung CY, Li X, Tian D, Wang JJ, Mitchell P, Cheng C-Y, Wong TY. Retinal Vein Occlusion in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Disease Study. Ophthalmic Epidemiol. 2016;23(1):6–13.

Published In

Ophthalmic Epidemiol

DOI

EISSN

1744-5086

Publication Date

2016

Volume

23

Issue

1

Start / End Page

6 / 13

Location

England

Related Subject Headings

  • Visual Acuity
  • Singapore
  • Risk Factors
  • Retinal Vein Occlusion
  • Prevalence
  • Middle Aged
  • Male
  • Humans
  • Female
  • Ethnicity