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Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.

Publication ,  Journal Article
Armstrong, MJ; Stang, MT; Liu, Y; Gao, J; Ren, B; Zuckerbraun, BS; Mahidhara, RS; Xing, Q; Pizzoferrato, E; Yim, JH
Published in: Cancer Lett
June 1, 2012

We have shown that the ectopic expression of Interferon Regulatory Factor 1 (IRF-1) results in human cancer cell death accompanied by the down-regulation of the Inhibitor of Apoptosis Protein (IAP) survivin and the induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). In this report, we investigated the direct role of p21 in the suppression of survivin. We show that IRF-1 down-regulates cyclin B1, cdc-2, cyclin E, E2F1, Cdk2, Cdk4, and results in p21-mediated G1 cell cycle arrest. Interestingly, while p21 directly mediates G1 cell cycle arrest, IRF-1 or other IRF-1 signaling pathways may directly regulate survivin in human cancer cells.

Duke Scholars

Published In

Cancer Lett

DOI

EISSN

1872-7980

Publication Date

June 1, 2012

Volume

319

Issue

1

Start / End Page

56 / 65

Location

Ireland

Related Subject Headings

  • Survivin
  • Oncology & Carcinogenesis
  • Neoplasm Proteins
  • Interferon Regulatory Factor-1
  • Inhibitor of Apoptosis Proteins
  • Humans
  • Down-Regulation
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cell Line, Tumor
  • Cell Cycle Checkpoints
 

Citation

APA
Chicago
ICMJE
MLA
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Armstrong, M. J., Stang, M. T., Liu, Y., Gao, J., Ren, B., Zuckerbraun, B. S., … Yim, J. H. (2012). Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells. Cancer Lett, 319(1), 56–65. https://doi.org/10.1016/j.canlet.2011.12.027
Armstrong, Michaele J., Michael T. Stang, Ye Liu, Jinbo Gao, Baoguo Ren, Brian S. Zuckerbraun, Raja S. Mahidhara, Quanhua Xing, Eva Pizzoferrato, and John H. Yim. “Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.Cancer Lett 319, no. 1 (June 1, 2012): 56–65. https://doi.org/10.1016/j.canlet.2011.12.027.
Armstrong MJ, Stang MT, Liu Y, Gao J, Ren B, Zuckerbraun BS, et al. Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells. Cancer Lett. 2012 Jun 1;319(1):56–65.
Armstrong, Michaele J., et al. “Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.Cancer Lett, vol. 319, no. 1, June 2012, pp. 56–65. Pubmed, doi:10.1016/j.canlet.2011.12.027.
Armstrong MJ, Stang MT, Liu Y, Gao J, Ren B, Zuckerbraun BS, Mahidhara RS, Xing Q, Pizzoferrato E, Yim JH. Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells. Cancer Lett. 2012 Jun 1;319(1):56–65.
Journal cover image

Published In

Cancer Lett

DOI

EISSN

1872-7980

Publication Date

June 1, 2012

Volume

319

Issue

1

Start / End Page

56 / 65

Location

Ireland

Related Subject Headings

  • Survivin
  • Oncology & Carcinogenesis
  • Neoplasm Proteins
  • Interferon Regulatory Factor-1
  • Inhibitor of Apoptosis Proteins
  • Humans
  • Down-Regulation
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cell Line, Tumor
  • Cell Cycle Checkpoints