Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Von Willebrand factor for menorrhagia: a survey and literature review.

Publication ,  Journal Article
Ragni, MV; Machin, N; Malec, LM; James, AH; Kessler, CM; Konkle, BA; Kouides, PA; Neff, AT; Philipp, CS; Brambilla, DJ
Published in: Haemophilia
May 2016

BACKGROUND: von Willebrand disease (VWD) is the most common congenital bleeding disorder. In women, menorrhagia is the most common bleeding symptom, and is disabling with iron deficiency anaemia, high health cost and poor quality of life. Current hormonal and non-hormonal therapies are limited by ineffectiveness and intolerance. Few data exist regarding von Willebrand factor (VWF), typically prescribed when other treatments fail. The lack of effective therapy for menorrhagia remains the greatest unmet healthcare need in women with VWD. Better therapies are needed to treat women with menorrhagia. METHODS: We conducted a survey of US haemophilia treatment centres (HTCs) and a literature review using medical subject heading (MeSH) search terms 'von Willebrand factor,' 'menorrhagia' and 'von Willebrand disease' to assess the use of VWF in menorrhagia. Analysis was by descriptive statistics. RESULTS: Of 83 surveys distributed to HTC MDs, 20 (24.1%) provided sufficient data for analysis. Of 1321 women with VWD seen during 2011-2014, 816 (61.8%) had menorrhagia, for which combined oral contraceptives, tranexamic acid and desmopressin were the most common first-line therapies for menorrhagia, whereas VWF was third-line therapy reported in 13 women (1.6%). Together with data from 88 women from six published studies, VWF safely reduced menorrhagia in 101 women at a dose of 33-100 IU kg(-1) on day 1-6 of menstrual cycle. CONCLUSIONS: This represents the largest VWD menorrhagia treatment experience to date. VWF safely and effectively reduces menorrhagia in women with VWD. A prospective clinical trial is planned to confirm these findings.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Haemophilia

DOI

EISSN

1365-2516

Publication Date

May 2016

Volume

22

Issue

3

Start / End Page

397 / 402

Location

England

Related Subject Headings

  • von Willebrand Factor
  • von Willebrand Diseases
  • Tranexamic Acid
  • Menorrhagia
  • Humans
  • Female
  • Deamino Arginine Vasopressin
  • Databases, Factual
  • Contraceptives, Oral
  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ragni, M. V., Machin, N., Malec, L. M., James, A. H., Kessler, C. M., Konkle, B. A., … Brambilla, D. J. (2016). Von Willebrand factor for menorrhagia: a survey and literature review. Haemophilia, 22(3), 397–402. https://doi.org/10.1111/hae.12898
Ragni, M. V., N. Machin, L. M. Malec, A. H. James, C. M. Kessler, B. A. Konkle, P. A. Kouides, A. T. Neff, C. S. Philipp, and D. J. Brambilla. “Von Willebrand factor for menorrhagia: a survey and literature review.Haemophilia 22, no. 3 (May 2016): 397–402. https://doi.org/10.1111/hae.12898.
Ragni MV, Machin N, Malec LM, James AH, Kessler CM, Konkle BA, et al. Von Willebrand factor for menorrhagia: a survey and literature review. Haemophilia. 2016 May;22(3):397–402.
Ragni, M. V., et al. “Von Willebrand factor for menorrhagia: a survey and literature review.Haemophilia, vol. 22, no. 3, May 2016, pp. 397–402. Pubmed, doi:10.1111/hae.12898.
Ragni MV, Machin N, Malec LM, James AH, Kessler CM, Konkle BA, Kouides PA, Neff AT, Philipp CS, Brambilla DJ. Von Willebrand factor for menorrhagia: a survey and literature review. Haemophilia. 2016 May;22(3):397–402.
Journal cover image

Published In

Haemophilia

DOI

EISSN

1365-2516

Publication Date

May 2016

Volume

22

Issue

3

Start / End Page

397 / 402

Location

England

Related Subject Headings

  • von Willebrand Factor
  • von Willebrand Diseases
  • Tranexamic Acid
  • Menorrhagia
  • Humans
  • Female
  • Deamino Arginine Vasopressin
  • Databases, Factual
  • Contraceptives, Oral
  • Cardiovascular System & Hematology