Skip to main content
Journal cover image

Preservation of myocardial high-energy phosphates with vagal stimulation and hypothermic cardioplegia.

Publication ,  Journal Article
Levett, JM; Ip, JH; Kadowaki, MH; Stennis, CA; Karp, RB
Published in: Ann Thorac Surg
February 1986

We examined three methods of inducing hypothermic cardioplegic arrest and related each to preservation of high-energy phosphates. Levels of adenosine triphosphate (ATP) and creatine phosphate (CP) in baseline rat hearts were compared with levels found after vagal stimulation combined with cardioplegia containing 15 mEq of potassium chloride (KCl) per liter, cardioplegia with 15 mEq of KCl per liter alone, and cardioplegia with 30 mEq of KCl per liter alone. Vagal stimulation produced complete electromechanical arrest in a shorter time than either 15 or 30 mEq of KCl alone (p less than 0.001 for both cardioplegic solutions compared with vagal stimulation), with fewer ventricular beats after ischemia than cardioplegic solution containing 15 or 30 mEq of KCl (p less than 0.001 and less than 0.01, respectively). Levels of ATP and CP, although less than baseline levels (p less than 0.01 and less than 0.001, respectively), were greater with vagal stimulation than with either 15 or 30 mEq of KCl (p less than 0.001 and less than 0.05, respectively, for ATP and p less than 0.001 for both CP levels). Furthermore, when all groups were combined, ATP and CP levels were found to correlate negatively with arrest time (r = -0.851 and -0.788, respectively; both r values significant at p less than 0.01) and with the number of ventricular beats after ischemia (r = -0.927 and -0.851, respectively; both r values significant at p less than 0.01). We conclude that electromechanical work quantified as time to arrest after aortic cross-clamping and as number of ventricular beats after ischemia correlates negatively with ATP and CP levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

February 1986

Volume

41

Issue

2

Start / End Page

150 / 154

Location

Netherlands

Related Subject Headings

  • Vagus Nerve
  • Respiratory System
  • Rats, Inbred Strains
  • Rats
  • Potassium Chloride
  • Phosphocreatine
  • Myocardium
  • Heart Rate
  • Heart Arrest, Induced
  • Electric Stimulation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Levett, J. M., Ip, J. H., Kadowaki, M. H., Stennis, C. A., & Karp, R. B. (1986). Preservation of myocardial high-energy phosphates with vagal stimulation and hypothermic cardioplegia. Ann Thorac Surg, 41(2), 150–154. https://doi.org/10.1016/s0003-4975(10)62656-2
Levett, J. M., J. H. Ip, M. H. Kadowaki, C. A. Stennis, and R. B. Karp. “Preservation of myocardial high-energy phosphates with vagal stimulation and hypothermic cardioplegia.Ann Thorac Surg 41, no. 2 (February 1986): 150–54. https://doi.org/10.1016/s0003-4975(10)62656-2.
Levett JM, Ip JH, Kadowaki MH, Stennis CA, Karp RB. Preservation of myocardial high-energy phosphates with vagal stimulation and hypothermic cardioplegia. Ann Thorac Surg. 1986 Feb;41(2):150–4.
Levett, J. M., et al. “Preservation of myocardial high-energy phosphates with vagal stimulation and hypothermic cardioplegia.Ann Thorac Surg, vol. 41, no. 2, Feb. 1986, pp. 150–54. Pubmed, doi:10.1016/s0003-4975(10)62656-2.
Levett JM, Ip JH, Kadowaki MH, Stennis CA, Karp RB. Preservation of myocardial high-energy phosphates with vagal stimulation and hypothermic cardioplegia. Ann Thorac Surg. 1986 Feb;41(2):150–154.
Journal cover image

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

February 1986

Volume

41

Issue

2

Start / End Page

150 / 154

Location

Netherlands

Related Subject Headings

  • Vagus Nerve
  • Respiratory System
  • Rats, Inbred Strains
  • Rats
  • Potassium Chloride
  • Phosphocreatine
  • Myocardium
  • Heart Rate
  • Heart Arrest, Induced
  • Electric Stimulation