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Hydrogels as carriers for stem cell transplantation.

Publication ,  Journal Article
Alvarado-Velez, M; Pai, SB; Bellamkonda, RV
Published in: IEEE transactions on bio-medical engineering
May 2014

Stem cells are a promising source for cell replacement therapy for several degenerative conditions. However, a number of limitations such as low cell survival, uncontrolled and/or low differentiation, induction of host immune response, and the risk of teratoma formation remain as challenges. In this review, we explore the utility of hydrogels as carriers for stem cell delivery and their potential to overcome some of the current limitations in stem cell therapy. We focus on in situ gelling hydrogels, and also discuss other strategies to modulate the immune response to promote controlled stem cell differentiation. Immunomodulatory hydrogels and gels designed to promote cell survival and integration into the host site will likely have a significant effect on enhancing the efficacy of stem cell transplantation as a therapy for debilitating degenerative diseases.

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Published In

IEEE transactions on bio-medical engineering

DOI

EISSN

1558-2531

ISSN

0018-9294

Publication Date

May 2014

Volume

61

Issue

5

Start / End Page

1474 / 1481

Related Subject Headings

  • Stem Cell Transplantation
  • Mice
  • Hydrogels
  • Humans
  • Cell Differentiation
  • Biomedical Engineering
  • Animals
  • 4603 Computer vision and multimedia computation
  • 4009 Electronics, sensors and digital hardware
  • 4003 Biomedical engineering
 

Citation

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Alvarado-Velez, M., Pai, S. B., & Bellamkonda, R. V. (2014). Hydrogels as carriers for stem cell transplantation. IEEE Transactions on Bio-Medical Engineering, 61(5), 1474–1481. https://doi.org/10.1109/tbme.2014.2305753
Alvarado-Velez, Melissa, S Balakrishna Pai, and Ravi V. Bellamkonda. “Hydrogels as carriers for stem cell transplantation.IEEE Transactions on Bio-Medical Engineering 61, no. 5 (May 2014): 1474–81. https://doi.org/10.1109/tbme.2014.2305753.
Alvarado-Velez M, Pai SB, Bellamkonda RV. Hydrogels as carriers for stem cell transplantation. IEEE transactions on bio-medical engineering. 2014 May;61(5):1474–81.
Alvarado-Velez, Melissa, et al. “Hydrogels as carriers for stem cell transplantation.IEEE Transactions on Bio-Medical Engineering, vol. 61, no. 5, May 2014, pp. 1474–81. Epmc, doi:10.1109/tbme.2014.2305753.
Alvarado-Velez M, Pai SB, Bellamkonda RV. Hydrogels as carriers for stem cell transplantation. IEEE transactions on bio-medical engineering. 2014 May;61(5):1474–1481.

Published In

IEEE transactions on bio-medical engineering

DOI

EISSN

1558-2531

ISSN

0018-9294

Publication Date

May 2014

Volume

61

Issue

5

Start / End Page

1474 / 1481

Related Subject Headings

  • Stem Cell Transplantation
  • Mice
  • Hydrogels
  • Humans
  • Cell Differentiation
  • Biomedical Engineering
  • Animals
  • 4603 Computer vision and multimedia computation
  • 4009 Electronics, sensors and digital hardware
  • 4003 Biomedical engineering