Scholars@Duke publication: Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI.

Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI.

Publication , Journal Article

van der Weg, K; Majidi, M; Haeck, JDE; Tijssen, JGP; Green, CL; Koch, KT; Kuijt, WJ; Krucoff, MW; Gorgels, APM; de Winter, RJ

Published in: J Electrocardiol

2016

Published version (DOI) Link to item

OBJECTIVE: We hypothesized that ventricular arrhythmia (VA) bursts during reperfusion phase are a marker of larger infarct size despite optimal epicardial and microvascular perfusion. METHODS: 126 STEMI patients were studied with 24h continuous, 12-lead Holter monitoring. Myocardial blush grade (MBG) was determined and VA bursts were identified against subject-specific background VA rates in core laboratories. Delayed-enhancement cardiovascular magnetic resonance imaging was used to determine infarct size. RESULTS: In the group with MBG 3 no significant differences were found for baseline characteristics between burst versus no burst (102 vs. 24). In those with optimal epicardial and microvascular reperfusion (TIMI 3, stable ST-recovery, and MBG 3), VA burst was associated with larger infarct size (N=102/126; median 11.0 vs. 5.1%; p=0.004). CONCLUSION: In the event of MBG 3, VA bursts were associated with significantly larger infarct size even if optimal epicardial and microvascular reperfusion was present.

Duke Scholars

Author Cynthia Lea Green Biostatistics & Bioinformatics, Division of Biostatistics

Author Mitchell Wolfe Krucoff Medicine, Cardiology

Published In

J Electrocardiol

DOI

10.1016/j.jelectrocard.2016.03.013

EISSN

1532-8430

Publication Date

2016

Volume

Issue

Start / End Page

345 / 352

Location

United States

Related Subject Headings

Ventricular Premature Complexes
Treatment Outcome
Sensitivity and Specificity
ST Elevation Myocardial Infarction
Risk Factors
Reproducibility of Results
Recovery of Function
Prognosis
Myocardial Reperfusion
Middle Aged

Citation

APA

Chicago

ICMJE

MLA

NLM

van der Weg, K., Majidi, M., Haeck, J. D. E., Tijssen, J. G. P., Green, C. L., Koch, K. T., … de Winter, R. J. (2016). Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI. J Electrocardiol, 49(3), 345–352. https://doi.org/10.1016/j.jelectrocard.2016.03.013

Weg, Kirian van der, Mohamed Majidi, Joost D. E. Haeck, Jan G. P. Tijssen, Cynthia L. Green, Karel T. Koch, Wichert J. Kuijt, Mitchell W. Krucoff, Anton P. M. Gorgels, and Robbert J. de Winter. “Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI.” J Electrocardiol 49, no. 3 (2016): 345–52. https://doi.org/10.1016/j.jelectrocard.2016.03.013.

van der Weg K, Majidi M, Haeck JDE, Tijssen JGP, Green CL, Koch KT, et al. Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI. J Electrocardiol. 2016;49(3):345–52.

van der Weg, Kirian, et al. “Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI.” J Electrocardiol, vol. 49, no. 3, 2016, pp. 345–52. Pubmed, doi:10.1016/j.jelectrocard.2016.03.013.

van der Weg K, Majidi M, Haeck JDE, Tijssen JGP, Green CL, Koch KT, Kuijt WJ, Krucoff MW, Gorgels APM, de Winter RJ. Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI. J Electrocardiol. 2016;49(3):345–352.

Published In

J Electrocardiol

DOI

10.1016/j.jelectrocard.2016.03.013

EISSN

1532-8430

Publication Date

2016

Volume

Issue

Start / End Page

345 / 352

Location

United States

Related Subject Headings

Ventricular Premature Complexes
Treatment Outcome
Sensitivity and Specificity
ST Elevation Myocardial Infarction
Risk Factors
Reproducibility of Results
Recovery of Function
Prognosis
Myocardial Reperfusion
Middle Aged