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Obesity, weight gain, and ovarian cancer risk in African American women.

Publication ,  Journal Article
Bandera, EV; Qin, B; Moorman, PG; Alberg, AJ; Barnholtz-Sloan, JS; Bondy, M; Cote, ML; Funkhouser, E; Peters, ES; Schwartz, AG; Terry, P ...
Published in: Int J Cancer
August 1, 2016

Although there is growing evidence that higher adiposity increases ovarian cancer risk, little is known about its impact in African American (AA) women, the racial/ethnic group with the highest prevalence of obesity. We evaluated the impact of body mass index (BMI) 1 year before diagnosis and weight gain since age 18 years on ovarian cancer risk in a population-based case-control study in AA women in 11 geographical areas in the US. Cases (n = 492) and age and site matched controls (n = 696) were identified through rapid case ascertainment and random-digit-dialing, respectively. Information was collected on demographic and lifestyle factors, including self-reported height, weight at age 18 and weight 1 year before diagnosis/interview. Multivariable logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI), adjusting for potential covariates. Obese women had elevated ovarian cancer risk, particularly for BMI ≥ 40 kg/m(2) compared to BMI <25 (OR = 1.72, 95% CI: 1.12-2.66; p for trend: 0.03). There was also a strong association with weight gain since age 18 (OR: 1.52; 95% CI: 1.07-2.16; p for trend: 0.02) comparing the highest to lowest quartile. In stratified analyses by menopausal status, the association with BMI and weight gain was limited to postmenopausal women, with a 15% (95% CI: 1.05-1.23) increase in risk per 5 kg/m(2) of BMI and 6% (95% CI: 1.01-1.10) increase in risk per 5 kg of weight gain. Excluding hormone therapy users essentially did not change results. Obesity and excessive adult weight gain may increase ovarian cancer risk in post-menopausal AA women.

Duke Scholars

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

August 1, 2016

Volume

139

Issue

3

Start / End Page

593 / 600

Location

United States

Related Subject Headings

  • Weight Gain
  • United States
  • Risk Factors
  • Population Surveillance
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Obesity
  • Neoplasm Grading
  • Middle Aged
 

Citation

APA
Chicago
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Bandera, E. V., Qin, B., Moorman, P. G., Alberg, A. J., Barnholtz-Sloan, J. S., Bondy, M., … Schildkraut, J. M. (2016). Obesity, weight gain, and ovarian cancer risk in African American women. Int J Cancer, 139(3), 593–600. https://doi.org/10.1002/ijc.30115
Bandera, Elisa V., Bo Qin, Patricia G. Moorman, Anthony J. Alberg, Jill S. Barnholtz-Sloan, Melissa Bondy, Michele L. Cote, et al. “Obesity, weight gain, and ovarian cancer risk in African American women.Int J Cancer 139, no. 3 (August 1, 2016): 593–600. https://doi.org/10.1002/ijc.30115.
Bandera EV, Qin B, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M, et al. Obesity, weight gain, and ovarian cancer risk in African American women. Int J Cancer. 2016 Aug 1;139(3):593–600.
Bandera, Elisa V., et al. “Obesity, weight gain, and ovarian cancer risk in African American women.Int J Cancer, vol. 139, no. 3, Aug. 2016, pp. 593–600. Pubmed, doi:10.1002/ijc.30115.
Bandera EV, Qin B, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M, Cote ML, Funkhouser E, Peters ES, Schwartz AG, Terry P, Schildkraut JM. Obesity, weight gain, and ovarian cancer risk in African American women. Int J Cancer. 2016 Aug 1;139(3):593–600.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

August 1, 2016

Volume

139

Issue

3

Start / End Page

593 / 600

Location

United States

Related Subject Headings

  • Weight Gain
  • United States
  • Risk Factors
  • Population Surveillance
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Obesity
  • Neoplasm Grading
  • Middle Aged