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Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region.

Publication ,  Journal Article
Castellsagué, X; Ault, KA; Bosch, FX; Brown, D; Cuzick, J; Ferris, DG; Joura, EA; Garland, SM; Giuliano, AR; Hernandez-Avila, M; Huh, W ...
Published in: Papillomavirus Res
December 2016

BACKGROUND: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region METHODS: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. RESULTS: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. CONCLUSIONS: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3.

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Published In

Papillomavirus Res

DOI

EISSN

2405-8521

Publication Date

December 2016

Volume

2

Start / End Page

61 / 69

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Uterine Cervical Dysplasia
  • Randomized Controlled Trials as Topic
  • Papillomaviridae
  • North America
  • Middle Aged
  • Latin America
  • Humans
  • Genotype
  • Female
 

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Castellsagué, X., Ault, K. A., Bosch, F. X., Brown, D., Cuzick, J., Ferris, D. G., … Velicer, C. (2016). Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region. Papillomavirus Res, 2, 61–69. https://doi.org/10.1016/j.pvr.2016.03.002
Castellsagué, Xavier, Kevin A. Ault, F Xavier Bosch, Darron Brown, Jack Cuzick, Daron G. Ferris, Elmar A. Joura, et al. “Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region.Papillomavirus Res 2 (December 2016): 61–69. https://doi.org/10.1016/j.pvr.2016.03.002.
Castellsagué X, Ault KA, Bosch FX, Brown D, Cuzick J, Ferris DG, et al. Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region. Papillomavirus Res. 2016 Dec;2:61–9.
Castellsagué, Xavier, et al. “Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region.Papillomavirus Res, vol. 2, Dec. 2016, pp. 61–69. Pubmed, doi:10.1016/j.pvr.2016.03.002.
Castellsagué X, Ault KA, Bosch FX, Brown D, Cuzick J, Ferris DG, Joura EA, Garland SM, Giuliano AR, Hernandez-Avila M, Huh W, Iversen O-E, Kjaer SK, Luna J, Monsonego J, Muñoz N, Myers E, Paavonen J, Pitisuttihum P, Steben M, Wheeler CM, Perez G, Saah A, Luxembourg A, Sings HL, Velicer C. Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region. Papillomavirus Res. 2016 Dec;2:61–69.
Journal cover image

Published In

Papillomavirus Res

DOI

EISSN

2405-8521

Publication Date

December 2016

Volume

2

Start / End Page

61 / 69

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Uterine Cervical Dysplasia
  • Randomized Controlled Trials as Topic
  • Papillomaviridae
  • North America
  • Middle Aged
  • Latin America
  • Humans
  • Genotype
  • Female