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Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents.

Publication ,  Journal Article
Dolan, LM; Bean, J; D'Alessio, D; Cohen, RM; Morrison, JA; Goodman, E; Daniels, SR
Published in: J Pediatr
June 2005

OBJECTIVE: To document the frequency of glucose intolerance in adolescents in a population-based study of primarily African-American/Non-Hispanic whites in an urban-suburban school district. STUDY DESIGN: Measurement of fasting and 2-hour post-glucose load plasma glucose concentrations. RESULTS: Carbohydrate intolerance (either impaired fasting glucose, impaired glucose tolerance, or both) was identified in 8.0%, near-diabetes (1 fasting glucose > or = 126 mg/dL [7.0 mmol/L] and/or 2-hour glucose > or = 200 mg/dL [11.1 mmol/L]) in 0.3%, and diabetes in 0.36% (type 1A = 0.24%; type 2 = 0.08%; undiagnosed type 2 = 0.04%). A model for abnormal carbohydrate metabolism was constructed with regression analysis in the Carbohydrate Intolerance (CI)/near-diabetes group and with logistic regression in the entire study population. Risk factors for the development of CI/near-diabetes included having a 1 unit increase in body mass index (BMI) z-score and either being non-Hispanic white or in the pubertal group. Increased fasting glucose correlated with having puberty and decreased BMI z-score, whereas 2-hour glucose correlated with increased BMI z-score. By using National Health and Nutrition Survey (NHANES) III (1988-1994) definitions, impaired fasting glucose was present in 2.0% in this study versus 1.7% (NHANES III). CONCLUSION: The prevalence of CI/near-diabetes was 8.3%. Undiagnosed diabetes mellitus was rare. One third of adolescents with diabetes mellitus could be classified as having type 2 diabetes mellitus. The adult model of the progression of insulin resistance to type 2 diabetes mellitus in adolescents may be valid. Despite the increase in the overweight population since NHANES III, abnormalities in glucose metabolism have not changed significantly.

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Published In

J Pediatr

DOI

ISSN

0022-3476

Publication Date

June 2005

Volume

146

Issue

6

Start / End Page

751 / 758

Location

United States

Related Subject Headings

  • Urban Population
  • Suburban Population
  • Risk Factors
  • Regression Analysis
  • Racial Groups
  • Puberty
  • Prospective Studies
  • Pediatrics
  • Ohio
  • Mass Screening
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dolan, L. M., Bean, J., D’Alessio, D., Cohen, R. M., Morrison, J. A., Goodman, E., & Daniels, S. R. (2005). Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents. J Pediatr, 146(6), 751–758. https://doi.org/10.1016/j.jpeds.2005.01.045
Dolan, Lawrence M., Judy Bean, David D’Alessio, Robert M. Cohen, John A. Morrison, Elizabeth Goodman, and Stephen R. Daniels. “Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents.J Pediatr 146, no. 6 (June 2005): 751–58. https://doi.org/10.1016/j.jpeds.2005.01.045.
Dolan LM, Bean J, D’Alessio D, Cohen RM, Morrison JA, Goodman E, et al. Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents. J Pediatr. 2005 Jun;146(6):751–8.
Dolan, Lawrence M., et al. “Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents.J Pediatr, vol. 146, no. 6, June 2005, pp. 751–58. Pubmed, doi:10.1016/j.jpeds.2005.01.045.
Dolan LM, Bean J, D’Alessio D, Cohen RM, Morrison JA, Goodman E, Daniels SR. Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents. J Pediatr. 2005 Jun;146(6):751–758.
Journal cover image

Published In

J Pediatr

DOI

ISSN

0022-3476

Publication Date

June 2005

Volume

146

Issue

6

Start / End Page

751 / 758

Location

United States

Related Subject Headings

  • Urban Population
  • Suburban Population
  • Risk Factors
  • Regression Analysis
  • Racial Groups
  • Puberty
  • Prospective Studies
  • Pediatrics
  • Ohio
  • Mass Screening