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Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII.

Publication ,  Journal Article
Clegg, DJ; Benoit, SC; Air, EL; Jackman, A; Tso, P; D'Alessio, D; Woods, SC; Seeley, RJ
Published in: Endocrinology
July 2003

The hypothalamic melanocortin (MC) system provides a critical inhibitory control on food intake and body weight. Because access to high-fat (HF) diets is associated with the development of obesity, we hypothesized that increased dietary fat attenuates signaling through the MC system. To evaluate this hypothesis, we compared the efficacy of the MC3/4 receptor agonist, MTII, to reduce food intake in rats fed carefully matched HF or low-fat (LF) diets for 12 wk. Rats given the HF diet ad libitum were significantly more obese than rats given the LF diet, and had significantly higher plasma insulin and leptin levels. MTII given into the third cerebral ventricle in doses of 0.1, 0.3, and 1.0 nmol was less effective at reducing food intake in HF rats than in LF rats. Whole-hypothalamic expression of the MC agonist precursor gene, proopiomelanocortin, the MC antagonist agouti-related protein, and the MC4 receptor, were not different between the HF and LF groups. These results indicate that consumption of a HF diet decreases signaling through the melanocortin system, an abnormality that could contribute to diet-induced obesity.

Duke Scholars

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

July 2003

Volume

144

Issue

7

Start / End Page

2941 / 2946

Location

United States

Related Subject Headings

  • alpha-MSH
  • Signal Transduction
  • Receptors, Corticotropin
  • Receptor, Melanocortin, Type 4
  • Receptor, Melanocortin, Type 3
  • Rats, Long-Evans
  • Rats
  • RNA, Messenger
  • Proteins
  • Pro-Opiomelanocortin
 

Citation

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MLA
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Clegg, D. J., Benoit, S. C., Air, E. L., Jackman, A., Tso, P., D’Alessio, D., … Seeley, R. J. (2003). Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology, 144(7), 2941–2946. https://doi.org/10.1210/en.2002-0218
Clegg, Deborah J., Stephen C. Benoit, Ellen L. Air, Alana Jackman, Patrick Tso, David D’Alessio, Stephen C. Woods, and Randy J. Seeley. “Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII.Endocrinology 144, no. 7 (July 2003): 2941–46. https://doi.org/10.1210/en.2002-0218.
Clegg DJ, Benoit SC, Air EL, Jackman A, Tso P, D’Alessio D, et al. Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology. 2003 Jul;144(7):2941–6.
Clegg, Deborah J., et al. “Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII.Endocrinology, vol. 144, no. 7, July 2003, pp. 2941–46. Pubmed, doi:10.1210/en.2002-0218.
Clegg DJ, Benoit SC, Air EL, Jackman A, Tso P, D’Alessio D, Woods SC, Seeley RJ. Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology. 2003 Jul;144(7):2941–2946.
Journal cover image

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

July 2003

Volume

144

Issue

7

Start / End Page

2941 / 2946

Location

United States

Related Subject Headings

  • alpha-MSH
  • Signal Transduction
  • Receptors, Corticotropin
  • Receptor, Melanocortin, Type 4
  • Receptor, Melanocortin, Type 3
  • Rats, Long-Evans
  • Rats
  • RNA, Messenger
  • Proteins
  • Pro-Opiomelanocortin