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Eating disorders and gastrointestinal peptides.

Publication ,  Journal Article
Tong, J; D'Alessio, D
Published in: Curr Opin Endocrinol Diabetes Obes
February 2011

PURPOSE OF REVIEW: Disturbances in gastrointestinal hormones have been implicated in the pathogenesis of eating disorders such as anorexia nervosa and bulimia nervosa. However, the contribution of these hormonal changes to the onset and maintenance of eating disorder remains unclear. We focus our review on a selective number of gastrointestinal hormones that are known to play a role in the regulation of short-term or long-term energy balance and examine their association with eating disorder in recently published literature. RECENT FINDINGS: Several new studies reported differential changes of ghrelin isoforms during fasting and following nutrient ingestion. New findings on other appetite-regulating hormones (peptide YY, cholecystokinin, incretin hormones and pancreatic polypeptide) at different nutritional states and disease stage have also been reported in subtypes of eating disorder. Most of the changes in peripheral hormones disappeared or partially recovered after the restoration of weight with nutritional and behavioral therapy. SUMMARY: Dysregulation of gastrointestinal hormones is more likely to contribute to the maintenance of the disordered eating behavior and related metabolic outcomes as well as the clinical course rather than causing them. A better understanding of this relationship also carries implications for developing targeted hormone-base treatment for eating disorder.

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Published In

Curr Opin Endocrinol Diabetes Obes

DOI

EISSN

1752-2978

Publication Date

February 2011

Volume

18

Issue

1

Start / End Page

42 / 49

Location

England

Related Subject Headings

  • Peptide YY
  • Peptide Hormones
  • Humans
  • Glucagon-Like Peptide 1
  • Ghrelin
  • Gastrointestinal Hormones
  • Feeding and Eating Disorders
  • Endocrinology & Metabolism
  • Cholecystokinin
  • Animals
 

Citation

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Tong, J., & D’Alessio, D. (2011). Eating disorders and gastrointestinal peptides. Curr Opin Endocrinol Diabetes Obes, 18(1), 42–49. https://doi.org/10.1097/MED.0b013e328341e12b
Tong, Jenny, and David D’Alessio. “Eating disorders and gastrointestinal peptides.Curr Opin Endocrinol Diabetes Obes 18, no. 1 (February 2011): 42–49. https://doi.org/10.1097/MED.0b013e328341e12b.
Tong J, D’Alessio D. Eating disorders and gastrointestinal peptides. Curr Opin Endocrinol Diabetes Obes. 2011 Feb;18(1):42–9.
Tong, Jenny, and David D’Alessio. “Eating disorders and gastrointestinal peptides.Curr Opin Endocrinol Diabetes Obes, vol. 18, no. 1, Feb. 2011, pp. 42–49. Pubmed, doi:10.1097/MED.0b013e328341e12b.
Tong J, D’Alessio D. Eating disorders and gastrointestinal peptides. Curr Opin Endocrinol Diabetes Obes. 2011 Feb;18(1):42–49.

Published In

Curr Opin Endocrinol Diabetes Obes

DOI

EISSN

1752-2978

Publication Date

February 2011

Volume

18

Issue

1

Start / End Page

42 / 49

Location

England

Related Subject Headings

  • Peptide YY
  • Peptide Hormones
  • Humans
  • Glucagon-Like Peptide 1
  • Ghrelin
  • Gastrointestinal Hormones
  • Feeding and Eating Disorders
  • Endocrinology & Metabolism
  • Cholecystokinin
  • Animals