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Association between Body Powder Use and Ovarian Cancer: The African American Cancer Epidemiology Study (AACES).

Publication ,  Journal Article
Schildkraut, JM; Abbott, SE; Alberg, AJ; Bandera, EV; Barnholtz-Sloan, JS; Bondy, ML; Cote, ML; Funkhouser, E; Peres, LC; Peters, ES; Terry, P ...
Published in: Cancer Epidemiol Biomarkers Prev
October 2016

BACKGROUND: Epidemiologic studies indicate increased ovarian cancer risk among women who use genital powder, but this has not been thoroughly investigated in African American (AA) women, a group with a high prevalence of use. We evaluate the relationship between use of genital powder and nongenital powder in invasive epithelial ovarian cancer (EOC). METHODS: Subjects are 584 cases and 745 controls enrolled in the African American Cancer Epidemiology Study (AACES), an ongoing, population-based case-control study of EOC in AA women in 11 geographic locations in the United States. AA controls were frequency matched to cases on residence and age. Logistic regression was used to calculate ORs and 95% confidence intervals (CI) for associations between genital and nongenital powder exposure and EOC risk, controlling for potential confounders. RESULTS: Powder use was common (62.8% of cases and 52.9% of controls). Genital powder was associated with an increased risk of EOC (OR = 1.44; 95% CI, 1.11-1.86) and a dose-response relationship was found for duration of use and number of lifetime applications (P < 0.05). Nongenital use was also associated with EOC risk, particularly among nonserous EOC cases (OR = 2.28; 95% CI, 1.39-3.74). An association between powder use and upper respiratory conditions suggests an enhanced inflammatory response may explain the association between body powder and EOC. CONCLUSIONS: In a study of AA women, body powder use was significantly associated with EOC risk. IMPACT: The results support that body powder is a modifiable risk factor for EOC among AA women. Cancer Epidemiol Biomarkers Prev; 25(10); 1411-7. ©2016 AACRSee related commentary by Trabert, p. 1369.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

October 2016

Volume

25

Issue

10

Start / End Page

1411 / 1417

Location

United States

Related Subject Headings

  • Young Adult
  • Powders
  • Ovarian Neoplasms
  • Odds Ratio
  • Neoplasms, Glandular and Epithelial
  • Middle Aged
  • Humans
  • Female
  • Epidemiology
  • Case-Control Studies
 

Citation

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Schildkraut, J. M., Abbott, S. E., Alberg, A. J., Bandera, E. V., Barnholtz-Sloan, J. S., Bondy, M. L., … Moorman, P. G. (2016). Association between Body Powder Use and Ovarian Cancer: The African American Cancer Epidemiology Study (AACES). Cancer Epidemiol Biomarkers Prev, 25(10), 1411–1417. https://doi.org/10.1158/1055-9965.EPI-15-1281
Schildkraut, Joellen M., Sarah E. Abbott, Anthony J. Alberg, Elisa V. Bandera, Jill S. Barnholtz-Sloan, Melissa L. Bondy, Michele L. Cote, et al. “Association between Body Powder Use and Ovarian Cancer: The African American Cancer Epidemiology Study (AACES).Cancer Epidemiol Biomarkers Prev 25, no. 10 (October 2016): 1411–17. https://doi.org/10.1158/1055-9965.EPI-15-1281.
Schildkraut JM, Abbott SE, Alberg AJ, Bandera EV, Barnholtz-Sloan JS, Bondy ML, et al. Association between Body Powder Use and Ovarian Cancer: The African American Cancer Epidemiology Study (AACES). Cancer Epidemiol Biomarkers Prev. 2016 Oct;25(10):1411–7.
Schildkraut, Joellen M., et al. “Association between Body Powder Use and Ovarian Cancer: The African American Cancer Epidemiology Study (AACES).Cancer Epidemiol Biomarkers Prev, vol. 25, no. 10, Oct. 2016, pp. 1411–17. Pubmed, doi:10.1158/1055-9965.EPI-15-1281.
Schildkraut JM, Abbott SE, Alberg AJ, Bandera EV, Barnholtz-Sloan JS, Bondy ML, Cote ML, Funkhouser E, Peres LC, Peters ES, Schwartz AG, Terry P, Crankshaw S, Camacho F, Wang F, Moorman PG. Association between Body Powder Use and Ovarian Cancer: The African American Cancer Epidemiology Study (AACES). Cancer Epidemiol Biomarkers Prev. 2016 Oct;25(10):1411–1417.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

October 2016

Volume

25

Issue

10

Start / End Page

1411 / 1417

Location

United States

Related Subject Headings

  • Young Adult
  • Powders
  • Ovarian Neoplasms
  • Odds Ratio
  • Neoplasms, Glandular and Epithelial
  • Middle Aged
  • Humans
  • Female
  • Epidemiology
  • Case-Control Studies