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Delayed administration of recombinant human parathyroid hormone improves early biomechanical strength in a rat rotator cuff repair model.

Publication ,  Journal Article
Duchman, KR; Goetz, JE; Uribe, BU; Amendola, AM; Barber, JA; Malandra, AE; Fredericks, DC; Hettrich, CM
Published in: J Shoulder Elbow Surg
August 2016

BACKGROUND: Despite advances in intraoperative techniques, rotator cuff repairs frequently do not heal. Recombinant human parathyroid hormone (rhPTH) has been shown to improve healing at the tendon-to-bone interface in an established acute rat rotator cuff repair model. We hypothesized that administration of rhPTH beginning on postoperative day 7 would result in improved early load to failure after acute rotator cuff repair in an established rat model. METHODS: Acute rotator cuff repairs were performed in 108 male Sprague-Dawley rats. Fifty-four rats received daily injections of rhPTH beginning on postoperative day 7 until euthanasia or a maximum of 12 weeks postoperatively. The remaining 54 rats received no injections and served as the control group. Animals were euthanized at 2 and 16 weeks postoperatively and evaluated by gross inspection, biomechanical testing, and histologic analysis. RESULTS: At 2 weeks postoperatively, rats treated with rhPTH demonstrated significantly higher load to failure than controls (10.9 vs. 5.2 N; P = .003). No difference in load to failure was found between the 2 groups at 16 weeks postoperatively, although control repairs more frequently failed at the tendon-to-bone interface (45.5% vs. 22.7%; P = .111). Blood vessel density appeared equivalent between the 2 groups at both time points, but increased intracellular and extracellular vascular endothelial growth factor expression was noted in the rhPTH-treated group at 2 weeks. CONCLUSIONS: Delayed daily administration of rhPTH resulted in increased early load to failure and equivalent blood vessel density in an acute rotator cuff repair model.

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Published In

J Shoulder Elbow Surg

DOI

EISSN

1532-6500

Publication Date

August 2016

Volume

25

Issue

8

Start / End Page

1280 / 1287

Location

United States

Related Subject Headings

  • Wound Healing
  • Weight-Bearing
  • Vascular Endothelial Growth Factor A
  • Teriparatide
  • Tensile Strength
  • Suture Techniques
  • Rotator Cuff Injuries
  • Rats, Sprague-Dawley
  • Rats
  • Orthopedics
 

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Duchman, K. R., Goetz, J. E., Uribe, B. U., Amendola, A. M., Barber, J. A., Malandra, A. E., … Hettrich, C. M. (2016). Delayed administration of recombinant human parathyroid hormone improves early biomechanical strength in a rat rotator cuff repair model. J Shoulder Elbow Surg, 25(8), 1280–1287. https://doi.org/10.1016/j.jse.2015.12.016
Duchman, Kyle R., Jessica E. Goetz, Bastian U. Uribe, Andrew M. Amendola, Joshua A. Barber, Allison E. Malandra, Douglas C. Fredericks, and Carolyn M. Hettrich. “Delayed administration of recombinant human parathyroid hormone improves early biomechanical strength in a rat rotator cuff repair model.J Shoulder Elbow Surg 25, no. 8 (August 2016): 1280–87. https://doi.org/10.1016/j.jse.2015.12.016.
Duchman KR, Goetz JE, Uribe BU, Amendola AM, Barber JA, Malandra AE, et al. Delayed administration of recombinant human parathyroid hormone improves early biomechanical strength in a rat rotator cuff repair model. J Shoulder Elbow Surg. 2016 Aug;25(8):1280–7.
Duchman, Kyle R., et al. “Delayed administration of recombinant human parathyroid hormone improves early biomechanical strength in a rat rotator cuff repair model.J Shoulder Elbow Surg, vol. 25, no. 8, Aug. 2016, pp. 1280–87. Pubmed, doi:10.1016/j.jse.2015.12.016.
Duchman KR, Goetz JE, Uribe BU, Amendola AM, Barber JA, Malandra AE, Fredericks DC, Hettrich CM. Delayed administration of recombinant human parathyroid hormone improves early biomechanical strength in a rat rotator cuff repair model. J Shoulder Elbow Surg. 2016 Aug;25(8):1280–1287.
Journal cover image

Published In

J Shoulder Elbow Surg

DOI

EISSN

1532-6500

Publication Date

August 2016

Volume

25

Issue

8

Start / End Page

1280 / 1287

Location

United States

Related Subject Headings

  • Wound Healing
  • Weight-Bearing
  • Vascular Endothelial Growth Factor A
  • Teriparatide
  • Tensile Strength
  • Suture Techniques
  • Rotator Cuff Injuries
  • Rats, Sprague-Dawley
  • Rats
  • Orthopedics