Skip to main content
Journal cover image

Allograft Versus Autograft Anterior Cruciate Ligament Reconstruction: Predictors of Failure From a MOON Prospective Longitudinal Cohort.

Publication ,  Journal Article
Kaeding, CC; Aros, B; Pedroza, A; Pifel, E; Amendola, A; Andrish, JT; Dunn, WR; Marx, RG; McCarty, EC; Parker, RD; Wright, RW; Spindler, KP
Published in: Sports Health
January 2011

BACKGROUND: Tearing an anterior cruciate ligament (ACL) graft is a devastating occurrence after ACL reconstruction (ACLR). Identifying and understanding the independent predictors of ACLR graft failure is important for surgical planning, patient counseling, and efforts to decrease the risk of graft failure. HYPOTHESIS: Patient and surgical variables will predict graft failure after ACLR. STUDY DESIGN: Prospective cohort study. METHODS: A multicenter group initiated a cohort study in 2002 to identify predictors of ACLR outcomes, including graft failure. First, to control for confounders, a single surgeon's data (n = 281 ACLRs) were used to develop a multivariable regression model for ACLR graft failure. Evaluated variables were graft type (autograft vs allograft), sex, age, body mass index, activity at index injury, presence of a meniscus tear, and primary versus revision reconstruction. Second, the model was validated with the rest of the multicenter study's data (n = 645 ACLRs) to evaluate the generalizability of the model. RESULTS: Patient age and ACL graft type were significant predictors of graft failure for all study surgeons. Patients in the age group of 10 to 19 years had the highest percentage of graft failures. The odds of graft rupture with an allograft reconstruction are 4 times higher than those of autograft reconstructions. For each 10-year decrease in age, the odds of graft rupture increase 2.3 times. CONCLUSION: There is an increased risk of ACL graft rupture in patients who have undergone allograft reconstruction. Younger patients also have an increased risk of ACL graft failure. CLINICAL RELEVANCE: Given these risks for ACL graft rupture, allograft ACLRs should be performed with caution in the younger patient population.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Sports Health

DOI

EISSN

1941-0921

Publication Date

January 2011

Volume

3

Issue

1

Start / End Page

73 / 81

Location

United States

Related Subject Headings

  • 4207 Sports science and exercise
  • 4201 Allied health and rehabilitation science
  • 3202 Clinical sciences
  • 1106 Human Movement and Sports Sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kaeding, C. C., Aros, B., Pedroza, A., Pifel, E., Amendola, A., Andrish, J. T., … Spindler, K. P. (2011). Allograft Versus Autograft Anterior Cruciate Ligament Reconstruction: Predictors of Failure From a MOON Prospective Longitudinal Cohort. Sports Health, 3(1), 73–81. https://doi.org/10.1177/1941738110386185
Kaeding, Christopher C., Brian Aros, Angela Pedroza, Eric Pifel, Annunziato Amendola, Jack T. Andrish, Warren R. Dunn, et al. “Allograft Versus Autograft Anterior Cruciate Ligament Reconstruction: Predictors of Failure From a MOON Prospective Longitudinal Cohort.Sports Health 3, no. 1 (January 2011): 73–81. https://doi.org/10.1177/1941738110386185.
Kaeding CC, Aros B, Pedroza A, Pifel E, Amendola A, Andrish JT, et al. Allograft Versus Autograft Anterior Cruciate Ligament Reconstruction: Predictors of Failure From a MOON Prospective Longitudinal Cohort. Sports Health. 2011 Jan;3(1):73–81.
Kaeding, Christopher C., et al. “Allograft Versus Autograft Anterior Cruciate Ligament Reconstruction: Predictors of Failure From a MOON Prospective Longitudinal Cohort.Sports Health, vol. 3, no. 1, Jan. 2011, pp. 73–81. Pubmed, doi:10.1177/1941738110386185.
Kaeding CC, Aros B, Pedroza A, Pifel E, Amendola A, Andrish JT, Dunn WR, Marx RG, McCarty EC, Parker RD, Wright RW, Spindler KP. Allograft Versus Autograft Anterior Cruciate Ligament Reconstruction: Predictors of Failure From a MOON Prospective Longitudinal Cohort. Sports Health. 2011 Jan;3(1):73–81.
Journal cover image

Published In

Sports Health

DOI

EISSN

1941-0921

Publication Date

January 2011

Volume

3

Issue

1

Start / End Page

73 / 81

Location

United States

Related Subject Headings

  • 4207 Sports science and exercise
  • 4201 Allied health and rehabilitation science
  • 3202 Clinical sciences
  • 1106 Human Movement and Sports Sciences
  • 1103 Clinical Sciences