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Adolescent development of insula-dependent interoceptive regulation.

Publication ,  Journal Article
Li, D; Zucker, NL; Kragel, PA; Covington, VE; LaBar, KS
Published in: Dev Sci
September 2017

Adolescence is hypothesized to be a critical period for the maturation of self-regulatory capacities, including those that depend on interoceptive sensitivity, but the neural basis of interoceptive regulation in adolescence is unknown. We used functional magnetic resonance imaging and psychophysiology to study interoceptive regulation in healthy adolescent females. Participants regulated their gut activities in response to a virtual roller coaster by deep breathing aided by visually monitoring their online electrogastrogram (EGG) activity through a virtual thermometer (i.e. gut biofeedback), or without biofeedback. Analyses focused on the insula, given its putative role in interoception. The bilateral posterior insula showed increased activation in the no-biofeedback compared to biofeedback condition, suggesting that the participants relied more on interoceptive input when exteroceptive feedback was unavailable. The bilateral dorsal anterior insula showed activation linearly associated with age during both induction and regulation, and its activation during regulation correlated positively with change of EGG in the tachygastria frequency band from induction to regulation. Induction-related activation in the bilateral ventral anterior insula was nonlinearly associated with age and peaked at mid-adolescence. These results implicate different developmental trajectories of distinct sub-regions of the insula in interoceptive processes, with implications for competing neurobiological theories of female adolescent development.

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Published In

Dev Sci

DOI

EISSN

1467-7687

Publication Date

September 2017

Volume

20

Issue

5

Location

England

Related Subject Headings

  • Young Adult
  • Psychophysics
  • Oxygen
  • Male
  • Magnetic Resonance Imaging
  • Interoception
  • Image Processing, Computer-Assisted
  • Humans
  • Female
  • Evoked Potentials
 

Citation

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Li, D., Zucker, N. L., Kragel, P. A., Covington, V. E., & LaBar, K. S. (2017). Adolescent development of insula-dependent interoceptive regulation. Dev Sci, 20(5). https://doi.org/10.1111/desc.12438
Li, Dawei, Nancy L. Zucker, Philip A. Kragel, Virginia E. Covington, and Kevin S. LaBar. “Adolescent development of insula-dependent interoceptive regulation.Dev Sci 20, no. 5 (September 2017). https://doi.org/10.1111/desc.12438.
Li D, Zucker NL, Kragel PA, Covington VE, LaBar KS. Adolescent development of insula-dependent interoceptive regulation. Dev Sci. 2017 Sep;20(5).
Li, Dawei, et al. “Adolescent development of insula-dependent interoceptive regulation.Dev Sci, vol. 20, no. 5, Sept. 2017. Pubmed, doi:10.1111/desc.12438.
Li D, Zucker NL, Kragel PA, Covington VE, LaBar KS. Adolescent development of insula-dependent interoceptive regulation. Dev Sci. 2017 Sep;20(5).
Journal cover image

Published In

Dev Sci

DOI

EISSN

1467-7687

Publication Date

September 2017

Volume

20

Issue

5

Location

England

Related Subject Headings

  • Young Adult
  • Psychophysics
  • Oxygen
  • Male
  • Magnetic Resonance Imaging
  • Interoception
  • Image Processing, Computer-Assisted
  • Humans
  • Female
  • Evoked Potentials