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Ethnic differences in the association between blood pressure components and chronic kidney disease in middle aged and older Asian adults.

Publication ,  Journal Article
Sabanayagam, C; Teo, BW; Tai, ES; Jafar, TH; Wong, TY
Published in: BMC Nephrol
April 17, 2013

BACKGROUND: Chronic kidney disease (CKD) is an emerging public health problem worldwide. Previous studies have shown an association between blood pressure (BP) and CKD. However, it is not clear if there are ethnic differences in this association. We examined the association between BP and CKD in a multi-ethnic Asian population in Singapore. METHODS: We analysed data from three large population-based studies conducted between 2004-2011, (n=3,167 Chinese, 3,082 Malays and 3,228 Indians) aged 40-80 years. CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m² from serum creatinine. Hypertension was defined as a self-reported current use of antihypertensive medication or systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg. We also analysed the association of CKD with individual BP components. RESULTS: The prevalence of both hypertension and CKD was higher among Malays (68.6, 21%) compared to Chinese (57.9, 5.9%) and Indians (56.0, 7.4%), but treatment for hypertension was lower among Malays (53.4%) compared to Chinese (89.8%) and Indians (83.1%). Hypertension was associated with CKD in all three ethnic groups (OR [95% CI] = 2.71 [1.59-4.63], 2.08 [1.62-2.68], 2.43 [1.66-3.57] in Chinese, Malays and Indians). Among the BP components, both systolic and diastolic BP were associated with CKD in Malays whereas, systolic BP was not significantly associated with CKD, and diastolic BP showed an inverse association which was explained by anti-hypertensive medication use in Chinese and Indians. CONCLUSIONS: Hypertension was associated with CKD in Chinese, Malays and Indians. However, the BP components were associated with CKD only in Malays.

Duke Scholars

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Published In

BMC Nephrol

DOI

EISSN

1471-2369

Publication Date

April 17, 2013

Volume

14

Start / End Page

86

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Population Surveillance
  • Middle Aged
  • Male
  • Malaysia
  • India
  • Humans
  • Female
  • Ethnicity
 

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Sabanayagam, C., Teo, B. W., Tai, E. S., Jafar, T. H., & Wong, T. Y. (2013). Ethnic differences in the association between blood pressure components and chronic kidney disease in middle aged and older Asian adults. BMC Nephrol, 14, 86. https://doi.org/10.1186/1471-2369-14-86
Sabanayagam, Charumathi, Boon Wee Teo, E Shyong Tai, Tazeen H. Jafar, and Tien Yin Wong. “Ethnic differences in the association between blood pressure components and chronic kidney disease in middle aged and older Asian adults.BMC Nephrol 14 (April 17, 2013): 86. https://doi.org/10.1186/1471-2369-14-86.
Sabanayagam, Charumathi, et al. “Ethnic differences in the association between blood pressure components and chronic kidney disease in middle aged and older Asian adults.BMC Nephrol, vol. 14, Apr. 2013, p. 86. Pubmed, doi:10.1186/1471-2369-14-86.
Journal cover image

Published In

BMC Nephrol

DOI

EISSN

1471-2369

Publication Date

April 17, 2013

Volume

14

Start / End Page

86

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Population Surveillance
  • Middle Aged
  • Male
  • Malaysia
  • India
  • Humans
  • Female
  • Ethnicity