Skip to main content
Journal cover image

A quantitative evaluation of inflammatory cells in human temporomandibular joint tissues from patients with and without implants.

Publication ,  Journal Article
Alonso, A; Kaimal, S; Look, J; Swift, J; Fricton, J; Myers, S; Kehl, L
Published in: J Oral Maxillofac Surg
April 2009

PURPOSE: Previous studies made only qualitative assessments of immune cell responses to temporomandibular joint (TMJ) implant wear debris. The aim of this study was to perform a quantitative comparison of inflammatory cell types in TMJ tissues with implant wear debris, TMJ tissues with a history of disc pathology without implant debris, and TMJ tissues from normal control subjects. MATERIALS AND METHODS: TMJ tissues were collected from the following 3 groups of subjects: 1) individuals with failed TMJ implants (implant group, n = 10), 2) patients with TMJ disc pathology but no history of implant placement (nonimplant surgery group, n = 10), and normal cadaveric tissues with no history of surgery (control group, n = 10). Tissue sections (5 microm) from all subjects were stained with hematoxylin-eosin, after which cell counts were done for 2 types of inflammatory cells: multinucleated giant cells and lymphocytes. Mean inflammatory cell counts from the 3 groups were compared by use of a 1-way analysis of variance procedure and Bonferroni adjustment to maintain an overall type I error rate of .05. RESULTS: Implant group tissues contained significantly more inflammatory cells than tissues from the nonimplant surgery and control groups (P < .0001). Multinucleated giant cells were only present in implant group tissues. Although the high number of multinucleated giant cells present in the implant group obscured a total count of lymphocytes for that group, lymphocyte cell counts were still significantly greater (P < .005) in implant group tissues than in tissues from the other 2 groups. CONCLUSIONS: Our data provide quantitative confirmation that the presence of Proplast-Teflon implant (Vitek, Houston, TX) wear debris is associated with a significant increase in the number of local multinucleated giant cells and lymphocytes.

Duke Scholars

Published In

J Oral Maxillofac Surg

DOI

EISSN

1531-5053

Publication Date

April 2009

Volume

67

Issue

4

Start / End Page

788 / 796

Location

United States

Related Subject Headings

  • Young Adult
  • Temporomandibular Joint Disorders
  • Temporomandibular Joint Disc
  • Temporomandibular Joint
  • Surface Properties
  • Prosthesis Failure
  • Proplast
  • Polytetrafluoroethylene
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Alonso, A., Kaimal, S., Look, J., Swift, J., Fricton, J., Myers, S., & Kehl, L. (2009). A quantitative evaluation of inflammatory cells in human temporomandibular joint tissues from patients with and without implants. J Oral Maxillofac Surg, 67(4), 788–796. https://doi.org/10.1016/j.joms.2008.09.010
Alonso, Aurelio, Shanti Kaimal, John Look, James Swift, James Fricton, Sandra Myers, and Lois Kehl. “A quantitative evaluation of inflammatory cells in human temporomandibular joint tissues from patients with and without implants.J Oral Maxillofac Surg 67, no. 4 (April 2009): 788–96. https://doi.org/10.1016/j.joms.2008.09.010.
Alonso A, Kaimal S, Look J, Swift J, Fricton J, Myers S, et al. A quantitative evaluation of inflammatory cells in human temporomandibular joint tissues from patients with and without implants. J Oral Maxillofac Surg. 2009 Apr;67(4):788–96.
Alonso, Aurelio, et al. “A quantitative evaluation of inflammatory cells in human temporomandibular joint tissues from patients with and without implants.J Oral Maxillofac Surg, vol. 67, no. 4, Apr. 2009, pp. 788–96. Pubmed, doi:10.1016/j.joms.2008.09.010.
Alonso A, Kaimal S, Look J, Swift J, Fricton J, Myers S, Kehl L. A quantitative evaluation of inflammatory cells in human temporomandibular joint tissues from patients with and without implants. J Oral Maxillofac Surg. 2009 Apr;67(4):788–796.
Journal cover image

Published In

J Oral Maxillofac Surg

DOI

EISSN

1531-5053

Publication Date

April 2009

Volume

67

Issue

4

Start / End Page

788 / 796

Location

United States

Related Subject Headings

  • Young Adult
  • Temporomandibular Joint Disorders
  • Temporomandibular Joint Disc
  • Temporomandibular Joint
  • Surface Properties
  • Prosthesis Failure
  • Proplast
  • Polytetrafluoroethylene
  • Middle Aged
  • Male