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Updates on the management of autoimmune blistering diseases.

Publication ,  Journal Article
Hooten, JN; Hall, RP; Cardones, AR
Published in: Skin Therapy Lett
2014

Autoimmune blistering diseases are rare, but potentially debilitating cutaneous disorders characterized by varying degrees of mucosal and cutaneous bullae formation. Topical therapy is appropriate for mild and even some moderate disease activity, but systemic treatment can be considered for more extensive involvement. Corticosteroids remain the first-line systemic therapy for patients with moderate to severe bullous pemphigoid and pemphigus vulgaris. While the use of systemic steroids has dramatically reduced mortality from these two autoimmune blistering disorders, treatment is also associated with multiple side effects, especially when used long-term. Steroid sparing agents, therefore, are invaluable in inducing long-term remission while minimizing steroid associated side effects. Treatment must be tailored to the individual patient's condition, and several other factors must be carefully considered in choosing appropriate therapy: 1) diagnosis, 2) severity of the condition and body site affected, 3) presence of comorbidities, and 4) ability to tolerate systemic therapy.

Duke Scholars

Published In

Skin Therapy Lett

ISSN

1201-5989

Publication Date

2014

Volume

19

Issue

5

Start / End Page

1 / 6

Location

Canada

Related Subject Headings

  • Skin Diseases
  • Severity of Illness Index
  • Pemphigus
  • Pemphigoid, Bullous
  • Humans
  • Glucocorticoids
  • Blister
  • Autoimmune Diseases
 

Citation

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Hooten, J. N., Hall, R. P., & Cardones, A. R. (2014). Updates on the management of autoimmune blistering diseases. Skin Therapy Lett, 19(5), 1–6.
Hooten, Joanna N., Russell P. Hall, and Adela R. Cardones. “Updates on the management of autoimmune blistering diseases.Skin Therapy Lett 19, no. 5 (2014): 1–6.
Hooten JN, Hall RP, Cardones AR. Updates on the management of autoimmune blistering diseases. Skin Therapy Lett. 2014;19(5):1–6.
Hooten, Joanna N., et al. “Updates on the management of autoimmune blistering diseases.Skin Therapy Lett, vol. 19, no. 5, 2014, pp. 1–6.
Hooten JN, Hall RP, Cardones AR. Updates on the management of autoimmune blistering diseases. Skin Therapy Lett. 2014;19(5):1–6.

Published In

Skin Therapy Lett

ISSN

1201-5989

Publication Date

2014

Volume

19

Issue

5

Start / End Page

1 / 6

Location

Canada

Related Subject Headings

  • Skin Diseases
  • Severity of Illness Index
  • Pemphigus
  • Pemphigoid, Bullous
  • Humans
  • Glucocorticoids
  • Blister
  • Autoimmune Diseases