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Targeted Anterior Gland Focal Therapy-a Novel Treatment Option for a Better Defined Disease.

Publication ,  Journal Article
Tay, KJ; Villers, A; Polascik, TJ
Published in: Curr Urol Rep
October 2016

The goal of focal therapy is to achieve long-term oncological control by eradicating only the clinically significant focus/foci of cancer within the prostate, while preserving erectile function and continence. Anterior prostate cancers may have a PZ or TZ origin and share commonalities in location and biology. While anterior prostate cancers previously constituted a diagnostic blind spot in the prostate and were often not detected or discovered late, with the rapid dissemination of advanced imaging and biopsy techniques, they can now be identified at an earlier, organ-confined stage due to MR imaging and targeted biopsies. Due to their anterior location, they represent a therapeutic target that allows for thorough ablation of the cancer focus/foci with an adequate margin while remaining far from the neurovascular bundles bilaterally. However, the TZ origin cancers are mostly anterior to the distal urethra close to the apex and the striated sphincter. Men having early stage anterior cancers may represent good candidates to achieve a balance between oncological control and functional preservation with focal therapy. Thus, this class of tumor based on location, along with the proposed treatment, represents a novel form of targeted image-guided therapy.

Duke Scholars

Published In

Curr Urol Rep

DOI

EISSN

1534-6285

Publication Date

October 2016

Volume

17

Issue

10

Start / End Page

69

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Ultrasonic Therapy
  • Prostatic Neoplasms
  • Male
  • Humans
  • Electrochemotherapy
  • Cryotherapy
  • Brachytherapy
 

Citation

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ICMJE
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Tay, K. J., Villers, A., & Polascik, T. J. (2016). Targeted Anterior Gland Focal Therapy-a Novel Treatment Option for a Better Defined Disease. Curr Urol Rep, 17(10), 69. https://doi.org/10.1007/s11934-016-0628-9
Tay, Kae Jack, Arnauld Villers, and Thomas J. Polascik. “Targeted Anterior Gland Focal Therapy-a Novel Treatment Option for a Better Defined Disease.Curr Urol Rep 17, no. 10 (October 2016): 69. https://doi.org/10.1007/s11934-016-0628-9.
Tay KJ, Villers A, Polascik TJ. Targeted Anterior Gland Focal Therapy-a Novel Treatment Option for a Better Defined Disease. Curr Urol Rep. 2016 Oct;17(10):69.
Tay, Kae Jack, et al. “Targeted Anterior Gland Focal Therapy-a Novel Treatment Option for a Better Defined Disease.Curr Urol Rep, vol. 17, no. 10, Oct. 2016, p. 69. Pubmed, doi:10.1007/s11934-016-0628-9.
Tay KJ, Villers A, Polascik TJ. Targeted Anterior Gland Focal Therapy-a Novel Treatment Option for a Better Defined Disease. Curr Urol Rep. 2016 Oct;17(10):69.
Journal cover image

Published In

Curr Urol Rep

DOI

EISSN

1534-6285

Publication Date

October 2016

Volume

17

Issue

10

Start / End Page

69

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Ultrasonic Therapy
  • Prostatic Neoplasms
  • Male
  • Humans
  • Electrochemotherapy
  • Cryotherapy
  • Brachytherapy