Skip to main content
Journal cover image

Sleep disturbance in euthymic bipolar patients.

Publication ,  Journal Article
Sylvia, LG; Dupuy, JM; Ostacher, MJ; Cowperthwait, CM; Hay, AC; Sachs, GS; Nierenberg, AA; Perlis, RH
Published in: J Psychopharmacol
August 2012

Sleep disturbance is a common feature during mood episodes in bipolar disorder. The aim of this study was to investigate the prevalence of such symptoms among euthymic bipolar patients, and their association with risk for mood episode recurrence. A cohort of bipolar I and II subjects participating in the Systematic Treatment Enhancement Program for Bipolar Disorder who were euthymic for at least 8 weeks were included in this analysis. Survival analysis was used to examine the association between sleep disturbance on the Montgomery-Asberg Depression Rating Scale (MADRS) and recurrence risk. A total of 73/483 bipolar I and II subjects reported at least mild sleep disturbance (MADRS sleep item ≥2) for the week prior to study entry. The presence of sleep problems was associated with a history of psychosis, number of previous suicide attempts, and anticonvulsant use. Sleep disturbance at study entry was significantly associated with risk for mood episode recurrence. Sleep disturbance is not uncommon between episodes for individuals with bipolar disorder and may be associated with a more severe course of illness. This suggests that sleep disturbance is an important prodromal symptom of bipolar disorder and should be considered a target for pharmacologic or psychosocial maintenance treatment.

Duke Scholars

Published In

J Psychopharmacol

DOI

EISSN

1461-7285

Publication Date

August 2012

Volume

26

Issue

8

Start / End Page

1108 / 1112

Location

United States

Related Subject Headings

  • Suicide, Attempted
  • Sleep Initiation and Maintenance Disorders
  • Recurrence
  • Psychotropic Drugs
  • Psychotic Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Humans
  • Female
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sylvia, L. G., Dupuy, J. M., Ostacher, M. J., Cowperthwait, C. M., Hay, A. C., Sachs, G. S., … Perlis, R. H. (2012). Sleep disturbance in euthymic bipolar patients. J Psychopharmacol, 26(8), 1108–1112. https://doi.org/10.1177/0269881111421973
Sylvia, Louisa G., Jamie M. Dupuy, Michael J. Ostacher, Colleen M. Cowperthwait, Aleena C. Hay, Gary S. Sachs, Andrew A. Nierenberg, and Roy H. Perlis. “Sleep disturbance in euthymic bipolar patients.J Psychopharmacol 26, no. 8 (August 2012): 1108–12. https://doi.org/10.1177/0269881111421973.
Sylvia LG, Dupuy JM, Ostacher MJ, Cowperthwait CM, Hay AC, Sachs GS, et al. Sleep disturbance in euthymic bipolar patients. J Psychopharmacol. 2012 Aug;26(8):1108–12.
Sylvia, Louisa G., et al. “Sleep disturbance in euthymic bipolar patients.J Psychopharmacol, vol. 26, no. 8, Aug. 2012, pp. 1108–12. Pubmed, doi:10.1177/0269881111421973.
Sylvia LG, Dupuy JM, Ostacher MJ, Cowperthwait CM, Hay AC, Sachs GS, Nierenberg AA, Perlis RH. Sleep disturbance in euthymic bipolar patients. J Psychopharmacol. 2012 Aug;26(8):1108–1112.
Journal cover image

Published In

J Psychopharmacol

DOI

EISSN

1461-7285

Publication Date

August 2012

Volume

26

Issue

8

Start / End Page

1108 / 1112

Location

United States

Related Subject Headings

  • Suicide, Attempted
  • Sleep Initiation and Maintenance Disorders
  • Recurrence
  • Psychotropic Drugs
  • Psychotic Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Humans
  • Female
  • Cohort Studies