Skip to main content
Journal cover image

Reproductive factors and ovarian cancer risk in African-American women.

Publication ,  Journal Article
Moorman, PG; Alberg, AJ; Bandera, EV; Barnholtz-Sloan, J; Bondy, M; Cote, ML; Funkhouser, E; Peters, ES; Schwartz, AG; Terry, P; Crankshaw, S ...
Published in: Annals of epidemiology
September 2016

Reproductive characteristics, the most established ovarian cancer risk factors, differ markedly between African-American and white women. Studies in predominantly white populations suggest that associations between reproductive characteristics and ovarian cancer vary by timing of the events and menopause status. This analysis examined associations between number, duration, and timing of reproductive events and epithelial ovarian cancer among African-American women.Data from a multicenter case-control study of ovarian cancer in African-American women (641 cases/752 controls) were used to examine associations with oral contraceptive (OC) use and pregnancy characteristics. Odds ratios (ORs) and 95% confidence intervals (CIs) associated with reproductive characteristics were calculated with logistic regression models.OC use (OR = 0.7, 95% CI 0.5-0.9), parity (OR = 0.5, 95% CI 0.3-0.6), and breastfeeding for >12 months (OR = 0.3, 95% CI 0.2-0.5) were inversely associated with ovarian cancer. More recent pregnancies and OC use had stronger associations with ovarian cancer than pregnancies or OC use that occurred earlier in life, especially among premenopausal women.This study provides the first thorough documentation that pregnancy, breastfeeding, and OC use are inversely associated with ovarian cancer in African-American women, similar to what has been observed in white women. The associations with timing of the exposures suggest that these factors have both short- and long-term effects.

Duke Scholars

Published In

Annals of epidemiology

DOI

EISSN

1873-2585

ISSN

1047-2797

Publication Date

September 2016

Volume

26

Issue

9

Start / End Page

654 / 662

Related Subject Headings

  • Young Adult
  • White People
  • United States
  • Risk Assessment
  • Reproductive History
  • Predictive Value of Tests
  • Parity
  • Ovarian Neoplasms
  • Odds Ratio
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moorman, P. G., Alberg, A. J., Bandera, E. V., Barnholtz-Sloan, J., Bondy, M., Cote, M. L., … Schildkraut, J. M. (2016). Reproductive factors and ovarian cancer risk in African-American women. Annals of Epidemiology, 26(9), 654–662. https://doi.org/10.1016/j.annepidem.2016.07.004
Moorman, Patricia G., Anthony J. Alberg, Elisa V. Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, et al. “Reproductive factors and ovarian cancer risk in African-American women.Annals of Epidemiology 26, no. 9 (September 2016): 654–62. https://doi.org/10.1016/j.annepidem.2016.07.004.
Moorman PG, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy M, Cote ML, et al. Reproductive factors and ovarian cancer risk in African-American women. Annals of epidemiology. 2016 Sep;26(9):654–62.
Moorman, Patricia G., et al. “Reproductive factors and ovarian cancer risk in African-American women.Annals of Epidemiology, vol. 26, no. 9, Sept. 2016, pp. 654–62. Epmc, doi:10.1016/j.annepidem.2016.07.004.
Moorman PG, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy M, Cote ML, Funkhouser E, Peters ES, Schwartz AG, Terry P, Crankshaw S, Wang F, Schildkraut JM. Reproductive factors and ovarian cancer risk in African-American women. Annals of epidemiology. 2016 Sep;26(9):654–662.
Journal cover image

Published In

Annals of epidemiology

DOI

EISSN

1873-2585

ISSN

1047-2797

Publication Date

September 2016

Volume

26

Issue

9

Start / End Page

654 / 662

Related Subject Headings

  • Young Adult
  • White People
  • United States
  • Risk Assessment
  • Reproductive History
  • Predictive Value of Tests
  • Parity
  • Ovarian Neoplasms
  • Odds Ratio
  • Middle Aged