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Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population.

Publication ,  Journal Article
Zhou, F; Qiu, L-X; Cheng, L; Wang, M-Y; Li, J; Sun, M-H; Yang, Y-J; Wang, J-C; Jin, L; Wang, Y-N; Wei, Q-Y
Published in: Oncotarget
December 13, 2016

Interleukin-17 plays a crucial role in inflammation-related carcinogenesis. We hypothesize that genetic variants in IL-17 are associated with gastric cancer (GCa) risk, and we genotyped five potentially functional single nucleotide polymorphisms (SNPs) (rs1974226 G > A, rs2275913 A > G, rs3819024 A > G, rs4711998 A > G, and rs8193036 C > T) of IL-17 in 1121 GCa patients and 1216 cancer-free controls in an eastern Chinese population. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Meta-analysis and genotype-mRNA expression correlation were performed to further validate positive associations. We found that an increased GCa risk was independently associated with rs1974226 (adjusted OR = 2.60, 95% CI = 1.27-5.32 for AA vs. GG + GA) and rs2275913 (adjusted OR = 1.33, 95% CI = 1.03-1.72 for GA + AA vs. GG), while a decreased GCa risk was independently associated with rs3819024 (adjusted OR = 0.72, 95% CI = 0.54-0.96 for GG vs. AA + AG). Additional meta-analyses confirmed the observed risk association with rs2275913. We also found that two IL-17 haplotypes (G-G-G-A-C) and (A-G-G-A-C) (in the order of rs1974226, rs2275913, rs3819024, rs4711998 and rs8193036) were associated with a reduced GCa risk (adjusted OR = 0.64, 95% CI = 0.46-0.89 and adjusted OR = 0.38, 95% CI = 0.17-0.81, respectively). However, the expression Quantitative Trait Locus (eQTL) analysis for the genotype-phenotype correlation did not find mRNA expression changes associated with either the genotypes. In conclusions, genetic variants of IL-17 are likely to be associated with risk of GCa, and additional larger studies with functional validation are needed to explore the molecular mechanisms underlying the observed associations.

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Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

December 13, 2016

Volume

7

Issue

50

Start / End Page

82384 / 82395

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Risk Assessment
  • RNA, Messenger
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Odds Ratio
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhou, F., Qiu, L.-X., Cheng, L., Wang, M.-Y., Li, J., Sun, M.-H., … Wei, Q.-Y. (2016). Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population. Oncotarget, 7(50), 82384–82395. https://doi.org/10.18632/oncotarget.11616
Zhou, Fei, Li-Xin Qiu, Lei Cheng, Meng-Yun Wang, Jin Li, Meng-Hong Sun, Ya-Jun Yang, et al. “Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population.Oncotarget 7, no. 50 (December 13, 2016): 82384–95. https://doi.org/10.18632/oncotarget.11616.
Zhou F, Qiu L-X, Cheng L, Wang M-Y, Li J, Sun M-H, et al. Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population. Oncotarget. 2016 Dec 13;7(50):82384–95.
Zhou, Fei, et al. “Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population.Oncotarget, vol. 7, no. 50, Dec. 2016, pp. 82384–95. Pubmed, doi:10.18632/oncotarget.11616.
Zhou F, Qiu L-X, Cheng L, Wang M-Y, Li J, Sun M-H, Yang Y-J, Wang J-C, Jin L, Wang Y-N, Wei Q-Y. Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population. Oncotarget. 2016 Dec 13;7(50):82384–82395.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

December 13, 2016

Volume

7

Issue

50

Start / End Page

82384 / 82395

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Risk Assessment
  • RNA, Messenger
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Odds Ratio
  • Middle Aged
  • Male