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A Case Report of Acute Cellular Rejection Following Intestinal Transplantation Managed With Adalimumab.

Publication ,  Journal Article
Rao, B; Jafri, S-M; Kazimi, M; Mullins, K; Raoufi, M; Segovia, MC
Published in: Transplant Proc
March 2016

There is a higher incidence of acute cellular rejection (ACR) in small bowel transplantation (SBT) compared with transplantation of other solid organs. Although there are reports on the use of infliximab to successfully treat ACR refractory to other treatments, there are no reports, to our knowledge, regarding the use of adalimumab. We present a case of a female patient with a history of Crohn's disease who underwent an isolated SBT and developed an episode of severe ACR. She was initially treated with methylprednisolone, thymoglobulin, basiliximab, and a dosage adjustment of tacrolimus. Results of repeat endoscopies and biopsies revealed no significant improvement. The patient initiated treatment with adalimumab every 2 weeks for a total of 6 months, in addition to maintenance treatment with prednisone and tacrolimus. Subsequent evaluations showed gradual improvement to normal mucosa and villi without ulceration. A regimen that incorporates adalimumab can thus be used to treat ACR after intestinal transplantation. Larger multicenter studies are needed to show the full efficacy of this therapeutic regimen.

Duke Scholars

Published In

Transplant Proc

DOI

EISSN

1873-2623

Publication Date

March 2016

Volume

48

Issue

2

Start / End Page

536 / 538

Location

United States

Related Subject Headings

  • Intestine, Small
  • Intestinal Mucosa
  • Humans
  • Graft Rejection
  • Female
  • Crohn Disease
  • Anti-Inflammatory Agents
  • Adult
  • Adalimumab
  • 3204 Immunology
 

Citation

APA
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ICMJE
MLA
NLM
Rao, B., Jafri, S.-M., Kazimi, M., Mullins, K., Raoufi, M., & Segovia, M. C. (2016). A Case Report of Acute Cellular Rejection Following Intestinal Transplantation Managed With Adalimumab. Transplant Proc, 48(2), 536–538. https://doi.org/10.1016/j.transproceed.2015.11.033
Rao, B., S. -. M. Jafri, M. Kazimi, K. Mullins, M. Raoufi, and M. C. Segovia. “A Case Report of Acute Cellular Rejection Following Intestinal Transplantation Managed With Adalimumab.Transplant Proc 48, no. 2 (March 2016): 536–38. https://doi.org/10.1016/j.transproceed.2015.11.033.
Rao B, Jafri S-M, Kazimi M, Mullins K, Raoufi M, Segovia MC. A Case Report of Acute Cellular Rejection Following Intestinal Transplantation Managed With Adalimumab. Transplant Proc. 2016 Mar;48(2):536–8.
Rao, B., et al. “A Case Report of Acute Cellular Rejection Following Intestinal Transplantation Managed With Adalimumab.Transplant Proc, vol. 48, no. 2, Mar. 2016, pp. 536–38. Pubmed, doi:10.1016/j.transproceed.2015.11.033.
Rao B, Jafri S-M, Kazimi M, Mullins K, Raoufi M, Segovia MC. A Case Report of Acute Cellular Rejection Following Intestinal Transplantation Managed With Adalimumab. Transplant Proc. 2016 Mar;48(2):536–538.
Journal cover image

Published In

Transplant Proc

DOI

EISSN

1873-2623

Publication Date

March 2016

Volume

48

Issue

2

Start / End Page

536 / 538

Location

United States

Related Subject Headings

  • Intestine, Small
  • Intestinal Mucosa
  • Humans
  • Graft Rejection
  • Female
  • Crohn Disease
  • Anti-Inflammatory Agents
  • Adult
  • Adalimumab
  • 3204 Immunology