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Does Quitting Smoking Make a Difference Among Newly Diagnosed Head and Neck Cancer Patients?

Publication ,  Journal Article
Choi, SH; Terrell, JE; Bradford, CR; Ghanem, T; Spector, ME; Wolf, GT; Lipkus, IM; Duffy, SA
Published in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
December 2016

To determine if smoking after a cancer diagnosis makes a difference in mortality among newly diagnosed head and neck cancer patients.Longitudinal data were collected from newly diagnosed head and neck cancer patients with a median follow-up time of 1627 days (N = 590). Mortality was censored at 8 years or September 1, 2011, whichever came first. Based on smoking status, all patients were categorized into four groups: continuing smokers, quitters, former smokers, or never-smokers. A broad range of covariates were included in the analyses. Kaplan-Meier curves, bivariate and multivariate Cox proportional hazards models were constructed.Eight-year overall mortality and cancer-specific mortality were 40.5% (239/590) and 25.4% (150/590), respectively. Smoking status after a cancer diagnosis predicted overall mortality and cancer-specific mortality. Compared to never-smokers, continuing smokers had the highest hazard ratio (HR) of dying from all causes (HR = 2.71, 95% confidence interval [CI] = 1.48-4.98). Those who smoked at diagnosis, but quit and did not relapse-quitters-had an improved hazard ratio of dying (HR = 2.38, 95% CI = 1.29-4.36) and former smokers at diagnosis with no relapse after diagnosis-former smokers-had the lowest hazard ratio of dying from all causes (HR = 1.68, 95% CI = 1.12-2.56). Similarly, quitters had a slightly higher hazard ratio of dying from cancer-specific reasons (HR = 2.38, 95% CI = 1.13-5.01) than never-smokers, which was similar to current smokers (HR = 2.07, 95% CI = 0.96-4.47), followed by former smokers (HR = 1.70, 95% CI = 1.00-2.89).Compared to never-smokers, continuing smokers have the highest HR of overall mortality followed by quitters and former smokers, which indicates that smoking cessation, even after a cancer diagnosis, may improve overall mortality among newly diagnosed head and neck cancer patients. Health care providers should consider incorporating smoking cessation interventions into standard cancer treatment to improve survival among this population.Using prospective observational longitudinal data from 590 head and neck cancer patients, this study showed that continuing smokers have the highest overall mortality relative to never-smokers, which indicates that smoking cessation, even after a cancer diagnosis, may have beneficial effects on long-term overall mortality. Health care providers should consider incorporating smoking cessation interventions into standard cancer treatment to improve survival among this population.

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Published In

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

DOI

EISSN

1469-994X

ISSN

1462-2203

Publication Date

December 2016

Volume

18

Issue

12

Start / End Page

2216 / 2224

Related Subject Headings

  • Young Adult
  • Survival Analysis
  • Surveys and Questionnaires
  • Smoking Prevention
  • Smoking Cessation
  • Smoking
  • Public Health
  • Prospective Studies
  • Proportional Hazards Models
  • Neoplasm Recurrence, Local
 

Citation

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ICMJE
MLA
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Choi, S. H., Terrell, J. E., Bradford, C. R., Ghanem, T., Spector, M. E., Wolf, G. T., … Duffy, S. A. (2016). Does Quitting Smoking Make a Difference Among Newly Diagnosed Head and Neck Cancer Patients? Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco, 18(12), 2216–2224. https://doi.org/10.1093/ntr/ntw189
Choi, Seung Hee, Jeffrey E. Terrell, Carol R. Bradford, Tamer Ghanem, Matthew E. Spector, Gregory T. Wolf, Isaac M. Lipkus, and Sonia A. Duffy. “Does Quitting Smoking Make a Difference Among Newly Diagnosed Head and Neck Cancer Patients?Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco 18, no. 12 (December 2016): 2216–24. https://doi.org/10.1093/ntr/ntw189.
Choi SH, Terrell JE, Bradford CR, Ghanem T, Spector ME, Wolf GT, et al. Does Quitting Smoking Make a Difference Among Newly Diagnosed Head and Neck Cancer Patients? Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2016 Dec;18(12):2216–24.
Choi, Seung Hee, et al. “Does Quitting Smoking Make a Difference Among Newly Diagnosed Head and Neck Cancer Patients?Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco, vol. 18, no. 12, Dec. 2016, pp. 2216–24. Epmc, doi:10.1093/ntr/ntw189.
Choi SH, Terrell JE, Bradford CR, Ghanem T, Spector ME, Wolf GT, Lipkus IM, Duffy SA. Does Quitting Smoking Make a Difference Among Newly Diagnosed Head and Neck Cancer Patients? Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2016 Dec;18(12):2216–2224.
Journal cover image

Published In

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

DOI

EISSN

1469-994X

ISSN

1462-2203

Publication Date

December 2016

Volume

18

Issue

12

Start / End Page

2216 / 2224

Related Subject Headings

  • Young Adult
  • Survival Analysis
  • Surveys and Questionnaires
  • Smoking Prevention
  • Smoking Cessation
  • Smoking
  • Public Health
  • Prospective Studies
  • Proportional Hazards Models
  • Neoplasm Recurrence, Local