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Dairy, calcium, vitamin D and ovarian cancer risk in African-American women.

Publication ,  Journal Article
Qin, B; Moorman, PG; Alberg, AJ; Barnholtz-Sloan, JS; Bondy, M; Cote, ML; Funkhouser, E; Peters, ES; Schwartz, AG; Terry, P; Schildkraut, JM ...
Published in: Br J Cancer
October 25, 2016

BACKGROUND: No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency. METHODS: We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African-American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: An increased ovarian cancer risk was observed for whole milk consumption and lactose intake (highest quartile vs lowest: OR=1.97, 95% CI: 1.25-3.10;P-trend: 0.008). Calcium intake was associated with a decreased risk of ovarian cancer (OR=0.51, 95 CI%: 0.30-0.86; P-trend: 0.009), but vitamin D intake was not. Longer sun exposure in summer months was found to predict a lower risk (OR=0.71, 95% CI: 0.51-0.99; P-trend: 0.049). CONCLUSIONS: Our findings suggest that a high-calcium, low-lactose diet, and sun exposure in summer months may reduce the risk of ovarian cancer in African-American women.

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Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

October 25, 2016

Volume

115

Issue

9

Start / End Page

1122 / 1130

Location

England

Related Subject Headings

  • Young Adult
  • Vitamin D Deficiency
  • Vitamin D
  • United States
  • Risk Factors
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Nutrition Surveys
  • Middle Aged
  • Humans
 

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Qin, B., Moorman, P. G., Alberg, A. J., Barnholtz-Sloan, J. S., Bondy, M., Cote, M. L., … Bandera, E. V. (2016). Dairy, calcium, vitamin D and ovarian cancer risk in African-American women. Br J Cancer, 115(9), 1122–1130. https://doi.org/10.1038/bjc.2016.289
Qin, Bo, Patricia G. Moorman, Anthony J. Alberg, Jill S. Barnholtz-Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, et al. “Dairy, calcium, vitamin D and ovarian cancer risk in African-American women.Br J Cancer 115, no. 9 (October 25, 2016): 1122–30. https://doi.org/10.1038/bjc.2016.289.
Qin B, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M, Cote ML, et al. Dairy, calcium, vitamin D and ovarian cancer risk in African-American women. Br J Cancer. 2016 Oct 25;115(9):1122–30.
Qin, Bo, et al. “Dairy, calcium, vitamin D and ovarian cancer risk in African-American women.Br J Cancer, vol. 115, no. 9, Oct. 2016, pp. 1122–30. Pubmed, doi:10.1038/bjc.2016.289.
Qin B, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M, Cote ML, Funkhouser E, Peters ES, Schwartz AG, Terry P, Schildkraut JM, Bandera EV. Dairy, calcium, vitamin D and ovarian cancer risk in African-American women. Br J Cancer. 2016 Oct 25;115(9):1122–1130.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

October 25, 2016

Volume

115

Issue

9

Start / End Page

1122 / 1130

Location

England

Related Subject Headings

  • Young Adult
  • Vitamin D Deficiency
  • Vitamin D
  • United States
  • Risk Factors
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Nutrition Surveys
  • Middle Aged
  • Humans