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Dietary inflammatory index and risk of epithelial ovarian cancer in African American women.

Publication ,  Journal Article
Peres, LC; Bandera, EV; Qin, B; Guertin, KA; Shivappa, N; Hebert, JR; Abbott, SE; Alberg, AJ; Barnholtz-Sloan, J; Bondy, M; Cote, ML; Wang, F ...
Published in: Int J Cancer
February 1, 2017

Chronic inflammation has been implicated in the development of epithelial ovarian cancer (EOC); yet the contribution of inflammatory foods and nutrients to EOC risk has been understudied. We investigated the association between the dietary inflammatory index (DII), a novel literature-derived tool to assess the inflammatory potential of one's diet, and EOC risk in African American (AA) women in the African American Cancer Epidemiology Study, the largest population-based case-control study of EOC in AA women to date. The energy-adjusted DII (E-DII) was computed per 1,000 kilocalories from dietary intake data collected through a food frequency questionnaire, which measured usual dietary intake in the year prior to diagnosis for cases or interview for controls. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression for the association between the E-DII and EOC risk. 493 cases and 662 controls were included in the analyses. We observed a 10% increase in EOC risk per a one-unit change in the E-DII (OR = 1.10, 95% CI = 1.03-1.17). Similarly, women consuming the most pro-inflammatory diet had a statistically significant increased EOC risk in comparison to the most anti-inflammatory diet (ORQuartile4/Quartile1  = 1.72; 95% CI = 1.18-2.51). We also observed effect modification by age (p < 0.05), where a strong, significant association between the E-DII and EOC risk was observed among women older than 60 years, but no association was observed in women aged 60 years or younger. Our findings suggest that a more pro-inflammatory diet was associated with an increased EOC risk, especially among women older than 60 years.

Duke Scholars

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

February 1, 2017

Volume

140

Issue

3

Start / End Page

535 / 543

Location

United States

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Neoplasms, Glandular and Epithelial
  • Middle Aged
  • Logistic Models
  • Inflammation
  • Humans
 

Citation

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Peres, L. C., Bandera, E. V., Qin, B., Guertin, K. A., Shivappa, N., Hebert, J. R., … Schildkraut, J. M. (2017). Dietary inflammatory index and risk of epithelial ovarian cancer in African American women. Int J Cancer, 140(3), 535–543. https://doi.org/10.1002/ijc.30467
Peres, Lauren C., Elisa V. Bandera, Bo Qin, Kristin A. Guertin, Nitin Shivappa, James R. Hebert, Sarah E. Abbott, et al. “Dietary inflammatory index and risk of epithelial ovarian cancer in African American women.Int J Cancer 140, no. 3 (February 1, 2017): 535–43. https://doi.org/10.1002/ijc.30467.
Peres LC, Bandera EV, Qin B, Guertin KA, Shivappa N, Hebert JR, et al. Dietary inflammatory index and risk of epithelial ovarian cancer in African American women. Int J Cancer. 2017 Feb 1;140(3):535–43.
Peres, Lauren C., et al. “Dietary inflammatory index and risk of epithelial ovarian cancer in African American women.Int J Cancer, vol. 140, no. 3, Feb. 2017, pp. 535–43. Pubmed, doi:10.1002/ijc.30467.
Peres LC, Bandera EV, Qin B, Guertin KA, Shivappa N, Hebert JR, Abbott SE, Alberg AJ, Barnholtz-Sloan J, Bondy M, Cote ML, Funkhouser E, Moorman PG, Peters ES, Schwartz AG, Terry PD, Camacho F, Wang F, Schildkraut JM. Dietary inflammatory index and risk of epithelial ovarian cancer in African American women. Int J Cancer. 2017 Feb 1;140(3):535–543.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

February 1, 2017

Volume

140

Issue

3

Start / End Page

535 / 543

Location

United States

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Neoplasms, Glandular and Epithelial
  • Middle Aged
  • Logistic Models
  • Inflammation
  • Humans