Skip to main content

Associations of maternal retinal vasculature with subsequent fetal growth and birth size.

Publication ,  Journal Article
Li, L-J; Aris, I; Su, LL; Tint, MT; Cheung, CY-L; Ikram, MK; Gluckman, P; Godfrey, KM; Tan, KH; Yeo, G; Yap, F; Kwek, K; Saw, S-M; Wong, T-Y ...
Published in: PLoS One
2015

OBJECTIVE: We aimed to study the maternal retinal microvasculature at mid-trimester and its relationship with subsequent fetal growth and birth size. METHODS: We recruited 732 pregnant women aged 18-46 years in the first trimester with singleton pregnancies. All had retinal photography and fetal scan performed at 26-28 weeks gestation, and subsequent fetal scan at 32-34 weeks gestation. Infant anthropometric measurements were done at birth. Retinal microvasculature was measured using computer software from the retinal photographs. RESULTS: In multiple linear regression models, each 10 μm narrowing in maternal retinal arteriolar caliber was associated with decreases of 1.36 mm in fetal head circumference at 32-34 weeks gestation, as well as decreases of 1.50 mm and 2.30 mm in infant head circumference and birth length at delivery, respectively. Each standard deviation decrease in maternal retinal arteriolar fractal dimension was associated with decreases of 1.55 mm in fetal head circumference at 32-34 weeks gestation, as well as decreases of 1.08 mm and 46.42 g in infant head circumference and birth weight at delivery, respectively. CONCLUSIONS: Narrower retinal arteriolar caliber and a sparser retinal vascular network in mothers, reflecting a suboptimal uteroplacental microvasculature during mid-pregnancy, were associated with poorer fetal growth and birth size.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

4

Start / End Page

e0118250

Location

United States

Related Subject Headings

  • Young Adult
  • Ultrasonography, Prenatal
  • Risk Factors
  • Retinal Vessels
  • Pregnancy
  • Middle Aged
  • Microvessels
  • Infant, Newborn
  • Humans
  • Gestational Age
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, L.-J., Aris, I., Su, L. L., Tint, M. T., Cheung, C.-L., Ikram, M. K., … Lee, Y. S. (2015). Associations of maternal retinal vasculature with subsequent fetal growth and birth size. PLoS One, 10(4), e0118250. https://doi.org/10.1371/journal.pone.0118250
Li, Ling-Jun, Izzuddin Aris, Lin Lin Su, Mya Thway Tint, Carol Yim-Lui Cheung, M Kamran Ikram, Peter Gluckman, et al. “Associations of maternal retinal vasculature with subsequent fetal growth and birth size.PLoS One 10, no. 4 (2015): e0118250. https://doi.org/10.1371/journal.pone.0118250.
Li L-J, Aris I, Su LL, Tint MT, Cheung CY-L, Ikram MK, et al. Associations of maternal retinal vasculature with subsequent fetal growth and birth size. PLoS One. 2015;10(4):e0118250.
Li, Ling-Jun, et al. “Associations of maternal retinal vasculature with subsequent fetal growth and birth size.PLoS One, vol. 10, no. 4, 2015, p. e0118250. Pubmed, doi:10.1371/journal.pone.0118250.
Li L-J, Aris I, Su LL, Tint MT, Cheung CY-L, Ikram MK, Gluckman P, Godfrey KM, Tan KH, Yeo G, Yap F, Kwek K, Saw S-M, Chong Y-S, Wong T-Y, Lee YS. Associations of maternal retinal vasculature with subsequent fetal growth and birth size. PLoS One. 2015;10(4):e0118250.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

4

Start / End Page

e0118250

Location

United States

Related Subject Headings

  • Young Adult
  • Ultrasonography, Prenatal
  • Risk Factors
  • Retinal Vessels
  • Pregnancy
  • Middle Aged
  • Microvessels
  • Infant, Newborn
  • Humans
  • Gestational Age