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Retinal microvasculature and cardiovascular health in childhood.

Publication ,  Journal Article
Gishti, O; Jaddoe, VWV; Felix, JF; Klaver, CCW; Hofman, A; Wong, TY; Ikram, MK; Gaillard, R
Published in: Pediatrics
April 2015

BACKGROUND AND OBJECTIVE: Alterations in retinal microvasculature are associated with increased risk of cardiovascular disease. We examined the associations of retinal vessel caliber with cardiovascular markers in school-age children. METHODS: Among 4007 school-age children (median age of 6.0 years), we measured cardiovascular markers and retinal vessel calibers from digitized retinal photographs. RESULTS: Narrower retinal arteriolar caliber was associated with higher systolic and diastolic blood pressure (-0.20 SD score [SDS] [95% confidence interval (CI) -0.24 to -0.18] and -0.14 SDS [-0.17 to -0.11], respectively, per SDS increase in retinal arteriolar caliber), mean arterial pressure, and pulse pressure, but not with carotid-femoral pulse wave velocity, heart rate, cardiac output, or left ventricular mass. A wider retinal venular caliber was associated with lower systolic blood pressure, mean arterial pressure, and pulse pressure and higher carotid-femoral pulse wave velocity (carotid-femoral pulse wave velocity difference = 0.04 SDS [95% CI 0.01 to 0.07] per SDS increase in retinal venular caliber). Both narrower retinal arteriolar and venular calibers were associated with higher risk of hypertension at the age of 6 years, with the strongest association for retinal arteriolar caliber (odds ratio 1.35 [95% CI 1.21 to 1.45] per SDS decrease in arteriolar caliber). Adjustment for parental and infant sociodemographic factors did not influence the observed associations. CONCLUSIONS: Both retinal arteriolar and venular calibers are associated with blood pressure in school-age children, whereas retinal venular caliber is associated with carotid-femoral pulse wave velocity. Microvascular adaptations in childhood might influence cardiovascular health and disease from childhood onward.

Duke Scholars

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Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

April 2015

Volume

135

Issue

4

Start / End Page

678 / 685

Location

United States

Related Subject Headings

  • Vascular Patency
  • Statistics as Topic
  • Risk Assessment
  • Retinal Vessels
  • Reference Values
  • Pulse Wave Analysis
  • Pediatrics
  • Netherlands
  • Microvessels
  • Male
 

Citation

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Chicago
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Gishti, O., Jaddoe, V. W. V., Felix, J. F., Klaver, C. C. W., Hofman, A., Wong, T. Y., … Gaillard, R. (2015). Retinal microvasculature and cardiovascular health in childhood. Pediatrics, 135(4), 678–685. https://doi.org/10.1542/peds.2014-3341
Gishti, Olta, Vincent W. V. Jaddoe, Janine F. Felix, Caroline C. W. Klaver, Albert Hofman, Tien Yin Wong, Mohammad Kamran Ikram, and Romy Gaillard. “Retinal microvasculature and cardiovascular health in childhood.Pediatrics 135, no. 4 (April 2015): 678–85. https://doi.org/10.1542/peds.2014-3341.
Gishti O, Jaddoe VWV, Felix JF, Klaver CCW, Hofman A, Wong TY, et al. Retinal microvasculature and cardiovascular health in childhood. Pediatrics. 2015 Apr;135(4):678–85.
Gishti, Olta, et al. “Retinal microvasculature and cardiovascular health in childhood.Pediatrics, vol. 135, no. 4, Apr. 2015, pp. 678–85. Pubmed, doi:10.1542/peds.2014-3341.
Gishti O, Jaddoe VWV, Felix JF, Klaver CCW, Hofman A, Wong TY, Ikram MK, Gaillard R. Retinal microvasculature and cardiovascular health in childhood. Pediatrics. 2015 Apr;135(4):678–685.

Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

April 2015

Volume

135

Issue

4

Start / End Page

678 / 685

Location

United States

Related Subject Headings

  • Vascular Patency
  • Statistics as Topic
  • Risk Assessment
  • Retinal Vessels
  • Reference Values
  • Pulse Wave Analysis
  • Pediatrics
  • Netherlands
  • Microvessels
  • Male