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Incidence of myocardial infarction, stroke, and death in patients with age-related macular degeneration treated with intravitreal anti-vascular endothelial growth factor therapy.

Publication ,  Journal Article
Ng, WY; Tan, GSW; Ong, P-G; Cheng, C-Y; Cheung, CY-L; Wong, DWK; Mathur, R; Chow, KY; Wong, TY; Cheung, GCM
Published in: Am J Ophthalmol
March 2015

PURPOSE: To describe the rates of myocardial infarction (MI), stroke, and mortality in patients who have treatment with intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections for age-related macular degeneration (AMD). DESIGN: A retrospective population linkage study. METHOD: We identified patients aged 40 years and above who received treatment with intravitreal anti-VEGF injections for AMD from January 1, 2008 to December 31, 2011 at the Singapore National Eye Centre. We used a national record linkage database to identify patients who developed MI, stroke, and all-cause mortality after the first injection, excluding those with previous MI or stroke at baseline from the respective analysis. We compared rates of MI, stroke, and mortality to that of the total Singapore population. RESULTS: A total of 1182 individuals had an intravitreal anti-VEGF injection included in this analysis, with the majority receiving bevacizumab (n = 1011). Overall, 19 patients developed MI, 16 developed stroke, and there were 43 mortalities, giving an age-adjusted incidence rate of 350.2 per 100 000 person-years for MI, 299.3 per 100 000 person-years for stroke, and 778.9 per 100 000 person-years for mortality. This is comparable to the weighted incidence rates of the Singapore population (427.1 per 100 000 person-years for MI, 340.4 per 100 000 person-years for stroke, and 921.3 per 100 000 person-years for mortality). CONCLUSION: The incidence rate of MI, stroke, and death in this cohort of AMD patients treated with anti-VEGF was low, and was not significantly higher than the age-adjusted incidence rate of these events in the Singapore population.

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Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

March 2015

Volume

159

Issue

3

Start / End Page

557 / 64.e1

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Stroke
  • Singapore
  • Retrospective Studies
  • Ophthalmology & Optometry
  • National Health Programs
  • Myocardial Infarction
  • Middle Aged
  • Medical Record Linkage
  • Male
 

Citation

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Ng, W. Y., Tan, G. S. W., Ong, P.-G., Cheng, C.-Y., Cheung, C.-L., Wong, D. W. K., … Cheung, G. C. M. (2015). Incidence of myocardial infarction, stroke, and death in patients with age-related macular degeneration treated with intravitreal anti-vascular endothelial growth factor therapy. Am J Ophthalmol, 159(3), 557-64.e1. https://doi.org/10.1016/j.ajo.2014.12.005
Ng, Wei Yan, Gavin Siew Wei Tan, Peng-Guan Ong, Ching-Yu Cheng, Carol Yim-Lui Cheung, Doric Wen Kuan Wong, Ranjana Mathur, Khuan Yew Chow, Tien Yin Wong, and Gemmy Chui Ming Cheung. “Incidence of myocardial infarction, stroke, and death in patients with age-related macular degeneration treated with intravitreal anti-vascular endothelial growth factor therapy.Am J Ophthalmol 159, no. 3 (March 2015): 557-64.e1. https://doi.org/10.1016/j.ajo.2014.12.005.
Ng, Wei Yan, et al. “Incidence of myocardial infarction, stroke, and death in patients with age-related macular degeneration treated with intravitreal anti-vascular endothelial growth factor therapy.Am J Ophthalmol, vol. 159, no. 3, Mar. 2015, pp. 557-64.e1. Pubmed, doi:10.1016/j.ajo.2014.12.005.
Ng WY, Tan GSW, Ong P-G, Cheng C-Y, Cheung CY-L, Wong DWK, Mathur R, Chow KY, Wong TY, Cheung GCM. Incidence of myocardial infarction, stroke, and death in patients with age-related macular degeneration treated with intravitreal anti-vascular endothelial growth factor therapy. Am J Ophthalmol. 2015 Mar;159(3):557–64.e1.
Journal cover image

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

March 2015

Volume

159

Issue

3

Start / End Page

557 / 64.e1

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Stroke
  • Singapore
  • Retrospective Studies
  • Ophthalmology & Optometry
  • National Health Programs
  • Myocardial Infarction
  • Middle Aged
  • Medical Record Linkage
  • Male