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Retinal vessel calibers predict long-term microvascular complications in type 1 diabetes: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987).

Publication ,  Journal Article
Broe, R; Rasmussen, ML; Frydkjaer-Olsen, U; Olsen, BS; Mortensen, HB; Hodgson, L; Wong, TY; Peto, T; Grauslund, J
Published in: Diabetes
November 2014

Diabetic neuropathy, nephropathy, and retinopathy cause significant morbidity in patients with type 1 diabetes, even though improvements in treatment modalities delay the appearance and reduce the severity of these complications. To prevent or further delay the onset, it is necessary to better understand common underlying pathogenesis and to discover preclinical biomarkers of these complications. Retinal vessel calibers have been associated with the presence of microvascular complications, but their long-term predictive value has only been sparsely investigated. We examined retinal vessel calibers as 16-year predictors of diabetic nephropathy, neuropathy, and proliferative retinopathy in a young population-based Danish cohort with type 1 diabetes. We used semiautomated computer software to analyze vessel diameters on baseline retinal photos. Calibers of all vessels coursing through a zone 0.5-1 disc diameter from the disc margin were measured and summarized as the central artery and vein equivalents. In multiple regression analyses, we found wider venular diameters and smaller arteriolar diameters were both predictive of the 16-year development of nephropathy, neuropathy, and proliferative retinopathy. Early retinal vessel caliber changes are seemingly early markers of microvascular processes, precede the development of microvascular complications, and are a potential noninvasive predictive test on future risk of diabetic retinopathy, neuropathy, and nephropathy.

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Published In

Diabetes

DOI

EISSN

1939-327X

Publication Date

November 2014

Volume

63

Issue

11

Start / End Page

3906 / 3914

Location

United States

Related Subject Headings

  • Young Adult
  • Retinal Vessels
  • Regression, Psychology
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetic Retinopathy
  • Diabetic Neuropathies
  • Diabetic Nephropathies
 

Citation

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Broe, R., Rasmussen, M. L., Frydkjaer-Olsen, U., Olsen, B. S., Mortensen, H. B., Hodgson, L., … Grauslund, J. (2014). Retinal vessel calibers predict long-term microvascular complications in type 1 diabetes: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987). Diabetes, 63(11), 3906–3914. https://doi.org/10.2337/db14-0227
Broe, Rebecca, Malin L. Rasmussen, Ulrik Frydkjaer-Olsen, Birthe S. Olsen, Henrik B. Mortensen, Lauren Hodgson, Tien Y. Wong, Tunde Peto, and Jakob Grauslund. “Retinal vessel calibers predict long-term microvascular complications in type 1 diabetes: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987).Diabetes 63, no. 11 (November 2014): 3906–14. https://doi.org/10.2337/db14-0227.
Broe R, Rasmussen ML, Frydkjaer-Olsen U, Olsen BS, Mortensen HB, Hodgson L, et al. Retinal vessel calibers predict long-term microvascular complications in type 1 diabetes: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987). Diabetes. 2014 Nov;63(11):3906–14.
Broe, Rebecca, et al. “Retinal vessel calibers predict long-term microvascular complications in type 1 diabetes: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987).Diabetes, vol. 63, no. 11, Nov. 2014, pp. 3906–14. Pubmed, doi:10.2337/db14-0227.
Broe R, Rasmussen ML, Frydkjaer-Olsen U, Olsen BS, Mortensen HB, Hodgson L, Wong TY, Peto T, Grauslund J. Retinal vessel calibers predict long-term microvascular complications in type 1 diabetes: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987). Diabetes. 2014 Nov;63(11):3906–3914.

Published In

Diabetes

DOI

EISSN

1939-327X

Publication Date

November 2014

Volume

63

Issue

11

Start / End Page

3906 / 3914

Location

United States

Related Subject Headings

  • Young Adult
  • Retinal Vessels
  • Regression, Psychology
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetic Retinopathy
  • Diabetic Neuropathies
  • Diabetic Nephropathies