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Retinal vascular caliber and age-related macular degeneration in an Indian population from Singapore.

Publication ,  Journal Article
Chin, YC; Wong, TY; Cheung, CMG; Cheung, CY-L; Zheng, Y; Mitchell, P; Huang, H; Wang, JJ; Ikram, MK
Published in: Ophthalmic Epidemiol
August 2014

PURPOSE: To examine the association between retinal vascular caliber and early age-related macular degeneration (AMD) in an Indian population. METHODS: A total of 3112 Indian participants aged ≥40 years from the population-based Singapore Indian Eye Study who had data available on retinal vascular caliber measurements and AMD status were included. Retinal arteriolar and venular calibers were measured from digital photographs using computer-assisted software according to a standardized protocol. Images of the macular region were graded according to the modified Wisconsin age-related maculopathy grading system. Right eyes were selected for analyses. Binary logistic regression models were used to assess the association, adjusting for age, sex, systolic blood pressure, total cholesterol, random blood glucose, body mass index, and the companion retinal vascular caliber. RESULTS: A total of 107 participants (3.4%) were diagnosed with early AMD. Neither arteriolar nor venular caliber was related to AMD. For early AMD, the age-, sex-, and companion retinal vascular caliber-adjusted odds ratio (OR) per standard deviation (SD) decrease in arteriolar caliber was 0.95 (95% CI 0.84-1.31; p = 0.671), and per SD increase in venular caliber was OR: 0.96 (95% CI: 0.77-1.20); p = 0.714. No trend was found after categorizing retinal vascular calibers into quartiles. Multivariate adjustment and stratified analyses did not alter these results. CONCLUSION: Retinal vascular calibers were not related to early AMD among Indian participants. These findings differ from those of several previous studies performed in Caucasian and Asian populations.

Duke Scholars

Published In

Ophthalmic Epidemiol

DOI

EISSN

1744-5086

Publication Date

August 2014

Volume

21

Issue

4

Start / End Page

224 / 229

Location

England

Related Subject Headings

  • Venules
  • Singapore
  • Retinal Vessels
  • Ocular Hypertension
  • Middle Aged
  • Male
  • Macular Degeneration
  • Logistic Models
  • India
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chin, Y. C., Wong, T. Y., Cheung, C. M. G., Cheung, C.-L., Zheng, Y., Mitchell, P., … Ikram, M. K. (2014). Retinal vascular caliber and age-related macular degeneration in an Indian population from Singapore. Ophthalmic Epidemiol, 21(4), 224–229. https://doi.org/10.3109/09286586.2014.926941
Chin, You Chuen, Tien Yin Wong, Chui Ming Gemmy Cheung, Carol Yim-Lui Cheung, Yingfeng Zheng, Paul Mitchell, HuiQi Huang, Jie Jin Wang, and Mohammad Kamran Ikram. “Retinal vascular caliber and age-related macular degeneration in an Indian population from Singapore.Ophthalmic Epidemiol 21, no. 4 (August 2014): 224–29. https://doi.org/10.3109/09286586.2014.926941.
Chin YC, Wong TY, Cheung CMG, Cheung CY-L, Zheng Y, Mitchell P, et al. Retinal vascular caliber and age-related macular degeneration in an Indian population from Singapore. Ophthalmic Epidemiol. 2014 Aug;21(4):224–9.
Chin, You Chuen, et al. “Retinal vascular caliber and age-related macular degeneration in an Indian population from Singapore.Ophthalmic Epidemiol, vol. 21, no. 4, Aug. 2014, pp. 224–29. Pubmed, doi:10.3109/09286586.2014.926941.
Chin YC, Wong TY, Cheung CMG, Cheung CY-L, Zheng Y, Mitchell P, Huang H, Wang JJ, Ikram MK. Retinal vascular caliber and age-related macular degeneration in an Indian population from Singapore. Ophthalmic Epidemiol. 2014 Aug;21(4):224–229.

Published In

Ophthalmic Epidemiol

DOI

EISSN

1744-5086

Publication Date

August 2014

Volume

21

Issue

4

Start / End Page

224 / 229

Location

England

Related Subject Headings

  • Venules
  • Singapore
  • Retinal Vessels
  • Ocular Hypertension
  • Middle Aged
  • Male
  • Macular Degeneration
  • Logistic Models
  • India
  • Humans