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Kidney and eye diseases: common risk factors, etiological mechanisms, and pathways.

Publication ,  Journal Article
Wong, CW; Wong, TY; Cheng, C-Y; Sabanayagam, C
Published in: Kidney Int
June 2014

Chronic kidney disease is an emerging health problem worldwide. The eye shares striking structural, developmental, and genetic pathways with the kidney, suggesting that kidney disease and ocular disease may be closely linked. A growing number of studies have found associations of chronic kidney disease with age-related macular degeneration, diabetic retinopathy, glaucoma, and cataract. In addition, retinal microvascular parameters have been shown to be predictive of chronic kidney disease. Chronic kidney disease shares common vascular risk factors including diabetes, hypertension, smoking, and obesity, and pathogenetic mechanisms including inflammation, oxidative stress, endothelial dysfunction, and microvascular dysfunction, with ocular diseases supporting the 'Common Soil Hypothesis.' In this review, we present major epidemiological evidence for these associations and explore underlying pathogenic mechanisms and common risk factors for kidney and ocular disease. Understanding the link between kidney and ocular disease can lead to the development of new treatment and screening strategies for both diseases.

Duke Scholars

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

June 2014

Volume

85

Issue

6

Start / End Page

1290 / 1302

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Signal Transduction
  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Predictive Value of Tests
  • Phenotype
  • Kidney Diseases
  • Humans
  • Genetic Predisposition to Disease
 

Citation

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Wong, C. W., Wong, T. Y., Cheng, C.-Y., & Sabanayagam, C. (2014). Kidney and eye diseases: common risk factors, etiological mechanisms, and pathways. Kidney Int, 85(6), 1290–1302. https://doi.org/10.1038/ki.2013.491
Wong, Chee Wai, Tien Yin Wong, Ching-Yu Cheng, and Charumathi Sabanayagam. “Kidney and eye diseases: common risk factors, etiological mechanisms, and pathways.Kidney Int 85, no. 6 (June 2014): 1290–1302. https://doi.org/10.1038/ki.2013.491.
Wong CW, Wong TY, Cheng C-Y, Sabanayagam C. Kidney and eye diseases: common risk factors, etiological mechanisms, and pathways. Kidney Int. 2014 Jun;85(6):1290–302.
Wong, Chee Wai, et al. “Kidney and eye diseases: common risk factors, etiological mechanisms, and pathways.Kidney Int, vol. 85, no. 6, June 2014, pp. 1290–302. Pubmed, doi:10.1038/ki.2013.491.
Wong CW, Wong TY, Cheng C-Y, Sabanayagam C. Kidney and eye diseases: common risk factors, etiological mechanisms, and pathways. Kidney Int. 2014 Jun;85(6):1290–1302.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

June 2014

Volume

85

Issue

6

Start / End Page

1290 / 1302

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Signal Transduction
  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Predictive Value of Tests
  • Phenotype
  • Kidney Diseases
  • Humans
  • Genetic Predisposition to Disease