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Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study.

Publication ,  Journal Article
Hilal, S; Saini, M; Tan, CS; Catindig, JA; Koay, WI; Niessen, WJ; Vrooman, HA; Wong, TY; Chen, C; Ikram, MK; Venketasubramanian, N
Published in: Alzheimer Dis Assoc Disord
2014

Cerebral microbleeds (CMBs) are considered to be a novel marker of cerebral small vessel disease. However, the link with cognitive impairment remains unclear. We investigated whether CMBs-independent of other traditional markers of cerebral small vessel disease-are related to cognition. Chinese subjects from the population-based Singapore Chinese Eye Study, who failed an initial cognitive screening and were recruited into the ongoing Epidemiology of Dementia in Singapore Study, underwent neuropsychological testing and 3 T brain magnetic resonance imaging. The presence and number of CMBs were graded using Brain Observer Microbleed Scale on susceptibility-weighted images. Other magnetic resonance imaging lesions that were graded included presence of lacunes, white matter lesion, and total brain volumes. A comprehensive neuropsychological battery was administered and cognitive function was summarized as composite and domain-specific Z-scores. Among 282 subjects, 91 had any CMBs (32.3%), of whom 36 (12.8%) had multiple CMBs. CMBs were-independent of cardiovascular risk factors and other markers of cerebral small vessel disease-significantly associated with poorer cognitive function as reflected by composite Z-score (mean difference per CMB increase: -0.06; 95% confidence interval: -0.11, -0.01] and with domain-specific Z-scores including executive function, attention, and visuoconstruction. Among Chinese subjects CMBs were, independent of other concomitant markers of cerebral small vessel disease, associated with poorer cognitive function.

Duke Scholars

Published In

Alzheimer Dis Assoc Disord

DOI

EISSN

1546-4156

Publication Date

2014

Volume

28

Issue

2

Start / End Page

106 / 112

Location

United States

Related Subject Headings

  • Singapore
  • Risk Factors
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Geriatrics
  • Female
  • Executive Function
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hilal, S., Saini, M., Tan, C. S., Catindig, J. A., Koay, W. I., Niessen, W. J., … Venketasubramanian, N. (2014). Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study. Alzheimer Dis Assoc Disord, 28(2), 106–112. https://doi.org/10.1097/WAD.0000000000000015
Hilal, Saima, Monica Saini, Chuen Seng Tan, Joseree A. Catindig, Way Inn Koay, Wiro J. Niessen, Henri A. Vrooman, et al. “Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study.Alzheimer Dis Assoc Disord 28, no. 2 (2014): 106–12. https://doi.org/10.1097/WAD.0000000000000015.
Hilal S, Saini M, Tan CS, Catindig JA, Koay WI, Niessen WJ, et al. Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study. Alzheimer Dis Assoc Disord. 2014;28(2):106–12.
Hilal, Saima, et al. “Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study.Alzheimer Dis Assoc Disord, vol. 28, no. 2, 2014, pp. 106–12. Pubmed, doi:10.1097/WAD.0000000000000015.
Hilal S, Saini M, Tan CS, Catindig JA, Koay WI, Niessen WJ, Vrooman HA, Wong TY, Chen C, Ikram MK, Venketasubramanian N. Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study. Alzheimer Dis Assoc Disord. 2014;28(2):106–112.

Published In

Alzheimer Dis Assoc Disord

DOI

EISSN

1546-4156

Publication Date

2014

Volume

28

Issue

2

Start / End Page

106 / 112

Location

United States

Related Subject Headings

  • Singapore
  • Risk Factors
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Geriatrics
  • Female
  • Executive Function