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Measurement of macular fractal dimension using a computer-assisted program.

Publication ,  Journal Article
Thomas, GN; Ong, S-Y; Tham, YC; Hsu, W; Lee, ML; Lau, QP; Tay, W; Alessi-Calandro, J; Hodgson, L; Kawasaki, R; Wong, TY; Cheung, CY
Published in: Invest Ophthalmol Vis Sci
April 9, 2014

PURPOSE: Macular diseases may be associated with an altered retinal vasculature. We describe and test new software for the measurement of retinal vascular fractal dimension to quantify the complexity of retinal vasculature at the macula (D mac) and to compare this with fractal dimension measured around the optic disc (D disc). METHODS: A total of 342 macular-centered and optic disc-centered digital retinal photographs from 171 subjects was selected randomly from a population-based study. Retinal vascular fractional dimension (Df) was measured by two trained graders using a computer-assisted program (SIVA-FA, software version 1.0, National University of Singapore) on macula-centered (D mac) and optic disc-centered (D disc) photographs, to assess intergrader reliability. Measurements were repeated after two weeks to determine intragrader reliability. A separate 50 pairs of consecutively repeated images were selected and measured using SIVA-FA to assess intrasession reliability. Reliability analyses were conducted using intraclass correlation coefficients (ICC), and multiple linear regression analyses were performed to compare factors associated with D mac and D disc measurements. RESULTS: The mean (SD) D mac and D disc values were 1.453 (0.060) and 1.484 (0.043), respectively, and were highly correlated (r = 0.70, P < 0.001). Intragrader, intergrader, and intrasession reliability for both Df measures was high (ICCs ranging from 0.88-0.99). In multiple regression analyses, age (both β = -0.03, P < 0.001) and hypertension (β = -0.02, P = 0.011; β = -0.02, P = 0.021, respectively) were independently associated with D mac and D disc. CONCLUSIONS: The complexity of the retinal vasculature in the macula can be measured reliably and may be a useful tool to study parafoveal vascular networks in macula diseases, such as diabetic maculopathy.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

April 9, 2014

Volume

55

Issue

4

Start / End Page

2237 / 2243

Location

United States

Related Subject Headings

  • Software
  • Reproducibility of Results
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Macula Lutea
  • Image Processing, Computer-Assisted
  • Humans
  • Fractals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Thomas, G. N., Ong, S.-Y., Tham, Y. C., Hsu, W., Lee, M. L., Lau, Q. P., … Cheung, C. Y. (2014). Measurement of macular fractal dimension using a computer-assisted program. Invest Ophthalmol Vis Sci, 55(4), 2237–2243. https://doi.org/10.1167/iovs.13-13315
Thomas, George N., Shin-Yeu Ong, Yih Chung Tham, Wynne Hsu, Mong Li Lee, Qiangfeng Peter Lau, Wanting Tay, et al. “Measurement of macular fractal dimension using a computer-assisted program.Invest Ophthalmol Vis Sci 55, no. 4 (April 9, 2014): 2237–43. https://doi.org/10.1167/iovs.13-13315.
Thomas GN, Ong S-Y, Tham YC, Hsu W, Lee ML, Lau QP, et al. Measurement of macular fractal dimension using a computer-assisted program. Invest Ophthalmol Vis Sci. 2014 Apr 9;55(4):2237–43.
Thomas, George N., et al. “Measurement of macular fractal dimension using a computer-assisted program.Invest Ophthalmol Vis Sci, vol. 55, no. 4, Apr. 2014, pp. 2237–43. Pubmed, doi:10.1167/iovs.13-13315.
Thomas GN, Ong S-Y, Tham YC, Hsu W, Lee ML, Lau QP, Tay W, Alessi-Calandro J, Hodgson L, Kawasaki R, Wong TY, Cheung CY. Measurement of macular fractal dimension using a computer-assisted program. Invest Ophthalmol Vis Sci. 2014 Apr 9;55(4):2237–2243.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

April 9, 2014

Volume

55

Issue

4

Start / End Page

2237 / 2243

Location

United States

Related Subject Headings

  • Software
  • Reproducibility of Results
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Macula Lutea
  • Image Processing, Computer-Assisted
  • Humans
  • Fractals