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Quantitative measurement of hard exudates in patients with diabetes and their associations with serum lipid levels.

Publication ,  Journal Article
Sasaki, M; Kawasaki, R; Noonan, JE; Wong, TY; Lamoureux, E; Wang, JJ
Published in: Invest Ophthalmol Vis Sci
August 15, 2013

PURPOSE: To describe a reproducible method of quantifying macular hard exudates (HEs) in diabetic maculopathy and determine the associations of HEs with systemic risk factors. METHODS: Patients with diabetes were recruited from a tertiary eye hospital in Melbourne, Australia. Total macular area covered by HEs (total HE area) and the distance from the foveal center to the nearest HE were measured in a semi-automated manner. Associations between HE parameters and diabetic complication risk factors were examined using multiple linear regression models. RESULTS: Of 593 participants (mean age 60.5-years old), 97 (16.4%) had HEs in at least one eye, due to diabetic maculopathy. The intraclass correlation coefficients (ICC) for inter- and intra-observer agreements were 0.982 and 0.999, respectively. Total HE area was positively associated with qualitative HE severity scale determined by photographic graders. The median of total HE area was 0.089 mm(2) (interquartile range, 0.027-0.246). The median distance between foveal center and the nearest HE was 791.1 μm (431.9-1385.4). After adjusting for age, sex, duration of diabetes, glycated hemoglobin, mean arterial pressure, diabetic retinopathy level, and use of lipid-lowering medication, low density lipoprotein (LDL) cholesterol (P = 0.009), and triglyceride levels (P = 0.036) were positively associated with total HE area. Higher triglyceride levels were associated with central involvement (P = 0.023). CONCLUSIONS: Quantitative measurement of HEs in patients with diabetes is associated with lipid levels, and higher triglyceride levels are associated with a higher risk of central involvement. Quantitative information may be useful to monitor HE progression or treatment response in persons with diabetic maculopathy.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

August 15, 2013

Volume

54

Issue

8

Start / End Page

5544 / 5550

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • ROC Curve
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Edema
  • Lipids
  • Humans
  • Female
 

Citation

APA
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ICMJE
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Sasaki, M., Kawasaki, R., Noonan, J. E., Wong, T. Y., Lamoureux, E., & Wang, J. J. (2013). Quantitative measurement of hard exudates in patients with diabetes and their associations with serum lipid levels. Invest Ophthalmol Vis Sci, 54(8), 5544–5550. https://doi.org/10.1167/iovs.13-11849
Sasaki, Mariko, Ryo Kawasaki, Jonathan E. Noonan, Tien Yin Wong, Ecosse Lamoureux, and Jie Jin Wang. “Quantitative measurement of hard exudates in patients with diabetes and their associations with serum lipid levels.Invest Ophthalmol Vis Sci 54, no. 8 (August 15, 2013): 5544–50. https://doi.org/10.1167/iovs.13-11849.
Sasaki M, Kawasaki R, Noonan JE, Wong TY, Lamoureux E, Wang JJ. Quantitative measurement of hard exudates in patients with diabetes and their associations with serum lipid levels. Invest Ophthalmol Vis Sci. 2013 Aug 15;54(8):5544–50.
Sasaki, Mariko, et al. “Quantitative measurement of hard exudates in patients with diabetes and their associations with serum lipid levels.Invest Ophthalmol Vis Sci, vol. 54, no. 8, Aug. 2013, pp. 5544–50. Pubmed, doi:10.1167/iovs.13-11849.
Sasaki M, Kawasaki R, Noonan JE, Wong TY, Lamoureux E, Wang JJ. Quantitative measurement of hard exudates in patients with diabetes and their associations with serum lipid levels. Invest Ophthalmol Vis Sci. 2013 Aug 15;54(8):5544–5550.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

August 15, 2013

Volume

54

Issue

8

Start / End Page

5544 / 5550

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • ROC Curve
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Edema
  • Lipids
  • Humans
  • Female