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Myopia, axial length, and age-related cataract: the Singapore Malay eye study.

Publication ,  Journal Article
Pan, C-W; Boey, PY; Cheng, C-Y; Saw, S-M; Tay, WT; Wang, JJ; Tan, AG; Mitchell, P; Wong, TY
Published in: Invest Ophthalmol Vis Sci
July 2, 2013

PURPOSE: To describe the associations of myopia and axial length (AL) with age-related cataract in an Asian population in Singapore. METHODS: A population-based cross-sectional study that examined 3280 (78.7% response) adults of Malay ethnicity aged 40 to 80 years. Refractive error was determined by subjective refraction and AL was measured using the Zeiss IOL-Master. Digital slit lamp and retroillumination lens photographs were taken and graded for age-related nuclear, cortical, and posterior subcapsular (PSC) cataract following the Wisconsin system. RESULTS: After excluding eyes with prior refractive or cataract surgery, 5474 eyes with gradable lens photographs were analyzed. In multivariate analyses adjusting for age, sex, body mass index, systolic blood pressure, glycosylated hemoglobin, smoking status, and education, myopia (spherical equivalent less than -0.5 diopter [D]) was associated with an increased prevalence of nuclear (OR: 4.99, 95% CI: 3.72–6.69) and PSC cataract (OR: 1.34, 95% CI: 1.30-1.39) but not with cortical cataract (OR: 0.85, 95% CI: 0.68-1.08) compared with emmetropia. Per-millimeter increase in AL was not associated with any of the three cataract subtypes. When myopia was defined as spherical equivalent of less than -5.0 D to -6.0 D, the OR of myopia for PSC cataract increased dramatically. CONCLUSIONS: Our study shows that myopia, but not AL, was associated with nuclear cataract, supporting the concept of index myopia with aging. Myopia, especially high myopia, may predispose to PSC cataract formation. Clinically, ophthalmologists should be aware that risk of PSC cataract appears to vary by refractive status.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 2, 2013

Volume

54

Issue

7

Start / End Page

4498 / 4502

Location

United States

Related Subject Headings

  • Singapore
  • Prevalence
  • Ophthalmology & Optometry
  • Myopia
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cross-Sectional Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Pan, C.-W., Boey, P. Y., Cheng, C.-Y., Saw, S.-M., Tay, W. T., Wang, J. J., … Wong, T. Y. (2013). Myopia, axial length, and age-related cataract: the Singapore Malay eye study. Invest Ophthalmol Vis Sci, 54(7), 4498–4502. https://doi.org/10.1167/iovs.13-12271
Pan, Chen-Wei, Pui Yi Boey, Ching-Yu Cheng, Seang-Mei Saw, Wan Ting Tay, Jie Jin Wang, Ava Grace Tan, Paul Mitchell, and Tien Yin Wong. “Myopia, axial length, and age-related cataract: the Singapore Malay eye study.Invest Ophthalmol Vis Sci 54, no. 7 (July 2, 2013): 4498–4502. https://doi.org/10.1167/iovs.13-12271.
Pan C-W, Boey PY, Cheng C-Y, Saw S-M, Tay WT, Wang JJ, et al. Myopia, axial length, and age-related cataract: the Singapore Malay eye study. Invest Ophthalmol Vis Sci. 2013 Jul 2;54(7):4498–502.
Pan, Chen-Wei, et al. “Myopia, axial length, and age-related cataract: the Singapore Malay eye study.Invest Ophthalmol Vis Sci, vol. 54, no. 7, July 2013, pp. 4498–502. Pubmed, doi:10.1167/iovs.13-12271.
Pan C-W, Boey PY, Cheng C-Y, Saw S-M, Tay WT, Wang JJ, Tan AG, Mitchell P, Wong TY. Myopia, axial length, and age-related cataract: the Singapore Malay eye study. Invest Ophthalmol Vis Sci. 2013 Jul 2;54(7):4498–4502.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 2, 2013

Volume

54

Issue

7

Start / End Page

4498 / 4502

Location

United States

Related Subject Headings

  • Singapore
  • Prevalence
  • Ophthalmology & Optometry
  • Myopia
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cross-Sectional Studies