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Impact of bilateral open and closed-angle glaucoma on glaucoma-specific functioning in Asians.

Publication ,  Journal Article
Wang, B; Aung, T; Marella, M; Zheng, Y; Wong, TY; Perera, S; Wong, TT; Ho, C-L; Lamoureux, EL
Published in: J Glaucoma
2013

PURPOSE: To evaluate the impact of bilateral primary glaucoma on glaucoma-specific functioning in Asians. METHODS: Patients with bilateral primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) aged 40 years or above of Chinese ethnicity in Singapore were recruited. All underwent a comprehensive clinical assessment of glaucoma. Glaucoma was diagnosed with a standard criteria including optic disc abnormality and visual field defect. The Glaucoma Quality of Life-15, a glaucoma-specific questionnaire, was used to evaluate the impact of glaucoma, and Rasch analysis was used to validate the Glaucoma Quality of Life-15. RESULTS: A total of 192 patients (mean±SD age, 65.73±17.6 y and 65.1% male) were recruited, of which 56.2% (n=108) and 43.8% (n=84) had POAG and PACG, respectively. Fifty-four (28.1%), 85 (44.3%), and 53 (27.6%) had bilateral mild glaucoma, mild glaucoma in 1 eye and moderate/severe glaucoma in the other, and bilateral moderate/severe glaucoma, respectively. In multivariate analyses, compared with patients with mild glaucoma in both eyes, those with (a) mild glaucoma in 1 eye and moderate/severe in other; and (b) moderate/severe glaucoma in both eyes, reported significantly poorer functioning (β-coefficient=-8.20; confidence interval, -14.36 to -2.04; P<0.05) and (β=-21.05; confidence interval, -28.06 to -14.04; P<0.05), respectively. A similar independent association was found for POAG and PACG. These associations were also considered to be clinically significant while comparing bilateral mild glaucoma with bilateral moderate/severe glaucoma. We however, found no significant difference for functioning and severity of glaucoma between PACG and POAG patients (P<0.05). CONCLUSIONS: Bilateral glaucoma is worse than the mild form in any eye and is significantly associated with poor glaucoma-specific functioning in this Singaporean Chinese sample. These data emphasize the need for strategies to identify patients early and prevent deterioration beyond the mild form of the condition.

Duke Scholars

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Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

2013

Volume

22

Issue

4

Start / End Page

330 / 335

Location

United States

Related Subject Headings

  • Visual Fields
  • Vision Disorders
  • Surveys and Questionnaires
  • Singapore
  • Sickness Impact Profile
  • Quality of Life
  • Psychometrics
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmology & Optometry
 

Citation

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ICMJE
MLA
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Wang, B., Aung, T., Marella, M., Zheng, Y., Wong, T. Y., Perera, S., … Lamoureux, E. L. (2013). Impact of bilateral open and closed-angle glaucoma on glaucoma-specific functioning in Asians. J Glaucoma, 22(4), 330–335. https://doi.org/10.1097/IJG.0b013e3182408593
Wang, Bingsong, Tin Aung, Manjula Marella, Yingfeng Zheng, Tien Y. Wong, Shamira Perera, Tina T. Wong, Ching-Lin Ho, and Ecosse L. Lamoureux. “Impact of bilateral open and closed-angle glaucoma on glaucoma-specific functioning in Asians.J Glaucoma 22, no. 4 (2013): 330–35. https://doi.org/10.1097/IJG.0b013e3182408593.
Wang B, Aung T, Marella M, Zheng Y, Wong TY, Perera S, et al. Impact of bilateral open and closed-angle glaucoma on glaucoma-specific functioning in Asians. J Glaucoma. 2013;22(4):330–5.
Wang, Bingsong, et al. “Impact of bilateral open and closed-angle glaucoma on glaucoma-specific functioning in Asians.J Glaucoma, vol. 22, no. 4, 2013, pp. 330–35. Pubmed, doi:10.1097/IJG.0b013e3182408593.
Wang B, Aung T, Marella M, Zheng Y, Wong TY, Perera S, Wong TT, Ho C-L, Lamoureux EL. Impact of bilateral open and closed-angle glaucoma on glaucoma-specific functioning in Asians. J Glaucoma. 2013;22(4):330–335.

Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

2013

Volume

22

Issue

4

Start / End Page

330 / 335

Location

United States

Related Subject Headings

  • Visual Fields
  • Vision Disorders
  • Surveys and Questionnaires
  • Singapore
  • Sickness Impact Profile
  • Quality of Life
  • Psychometrics
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmology & Optometry