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Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study.

Publication ,  Journal Article
Hilal, S; Ikram, MK; Saini, M; Tan, CS; Catindig, JA; Dong, YH; Lim, LBS; Ting, EYS; Koo, EH; Cheung, CYL; Qiu, A; Wong, TY; Chen, CL-H ...
Published in: J Neurol Neurosurg Psychiatry
June 2013

OBJECTIVE: To study the prevalence of and associated factors for cognitive impairment and dementia in community dwelling Chinese from Singapore. METHODS: This study includes Chinese subjects from the Epidemiology of Dementia in Singapore (EDIS) study, aged ≥60 years, who underwent comprehensive examinations, including cognitive screening with the locally validated Abbreviated Mental Test and Progressive Forgetfulness Questionnaire. Screen positive participants subsequently underwent extensive neuropsychological testing and cerebral MRI. Cognitive impairment no dementia (CIND) and dementia were diagnosed according to internationally accepted criteria. The prevalence of cognitive impairment and dementia were computed per 5 year age categories and gender. To examine the relationship between baseline associated factors and cognitive impairment, we used logistic regression models to compute odd ratios with 95% CI. RESULTS: 1538 Chinese subjects, aged ≥60 years, underwent cognitive screening: 171 (15.2%) were diagnosed with any cognitive impairment, of whom 84 were CIND mild, 80 CIND moderate and seven had dementia. The overall age adjusted prevalence of CIND mild was 7.2%; CIND moderate/dementia was 7.9%. The prevalence increased with age, from 5.9% in those aged 60-64 years to 31.3% in those aged 75-79 years and 44.1% in those aged ≥80 years. Multivariate analysis revealed age, diabetes and hyperlipidaemia to be independently associated with cognitive impairment. CONCLUSIONS: In present study, the overall prevalence of cognitive impairment and dementia in Chinese was 15.2%, which is in the same range as the prevalence reported in Caucasian and other Asian populations.

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Published In

J Neurol Neurosurg Psychiatry

DOI

EISSN

1468-330X

Publication Date

June 2013

Volume

84

Issue

6

Start / End Page

686 / 692

Location

England

Related Subject Headings

  • Singapore
  • Sex Factors
  • Prevalence
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Neuroimaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Hilal, S., Ikram, M. K., Saini, M., Tan, C. S., Catindig, J. A., Dong, Y. H., … Venketasubramanian, N. (2013). Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study. J Neurol Neurosurg Psychiatry, 84(6), 686–692. https://doi.org/10.1136/jnnp-2012-304080
Hilal, Saima, Mohammad Kamran Ikram, Monica Saini, Chuen Seng Tan, Joseree Ann Catindig, Yan Hong Dong, Leon Ben Swie Lim, et al. “Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study.J Neurol Neurosurg Psychiatry 84, no. 6 (June 2013): 686–92. https://doi.org/10.1136/jnnp-2012-304080.
Hilal S, Ikram MK, Saini M, Tan CS, Catindig JA, Dong YH, et al. Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study. J Neurol Neurosurg Psychiatry. 2013 Jun;84(6):686–92.
Hilal, Saima, et al. “Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study.J Neurol Neurosurg Psychiatry, vol. 84, no. 6, June 2013, pp. 686–92. Pubmed, doi:10.1136/jnnp-2012-304080.
Hilal S, Ikram MK, Saini M, Tan CS, Catindig JA, Dong YH, Lim LBS, Ting EYS, Koo EH, Cheung CYL, Qiu A, Wong TY, Chen CL-H, Venketasubramanian N. Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study. J Neurol Neurosurg Psychiatry. 2013 Jun;84(6):686–692.

Published In

J Neurol Neurosurg Psychiatry

DOI

EISSN

1468-330X

Publication Date

June 2013

Volume

84

Issue

6

Start / End Page

686 / 692

Location

England

Related Subject Headings

  • Singapore
  • Sex Factors
  • Prevalence
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Neuroimaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans