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Relationship between intraocular pressure and angle configuration: an anterior segment OCT study.

Publication ,  Journal Article
Chong, RS; Sakata, LM; Narayanaswamy, AK; Ho, S-W; He, M; Baskaran, M; Wong, TY; Perera, SA; Aung, T
Published in: Invest Ophthalmol Vis Sci
March 5, 2013

PURPOSE: To assess the relationship between intraocular pressure (IOP) and anterior chamber angle (ACA) configuration as assessed by gonioscopy and anterior segment optical coherence tomography (AS-OCT). METHODS: A total of 2045 subjects aged 50 years and older, were recruited from a community clinic and underwent AS-OCT, Goldmann applanation tonometry, and gonioscopy. A quadrant was classified as closed on gonioscopy if the posterior trabecular meshwork could not be seen. A closed quadrant on AS-OCT was defined by the presence of any contact between the iris and angle wall anterior to the scleral spur. Customized software (Zhongshan Angle Assessment Program, Guangzhou, China) was used to measure AS-OCT parameters on AS-OCT scans, including anterior chamber depth, area, and volume; iris thickness (IT) and curvature; lens vault; angle opening distance; and trabecular-iris space area. IOP values were adjusted for age, sex, diabetes and hypertension status, body mass index, central corneal thickness, and presence of peripheral anterior synechiae. RESULTS: Mean age of study subjects was 63.2 ± 8.0 years, 52.6% were female, and 89.4% were Chinese. Mean IOP was 14.8 ± 2.4 mm Hg (range 826). IOP (mean ± SE) increased with number of quadrants with gonioscopic angle closure (none: 14.6 ± 0.2; one: 14.7 ± 0.3; two: 15.0 ± 0.3; three: 15.0 ± 0.3; four: 15.6 ± 0.3 mm Hg; P < 0.001), and on AS-OCT (none: 14.7 ± 0.2; one: 15.0 ± 0.2; two: 14.8 ± 0.2; three: 15.1 ± 0.3; four: 16.0 ± 0.3 mm Hg; P < 0.001). IOP also increased in association with most of the ACA quantitative parameters measured on AS-OCT images, except for IT and lens vault. CONCLUSIONS: There was an association between the extent of angle closure, as assessed on AS-OCT and gonioscopy, with increasing IOP.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

March 5, 2013

Volume

54

Issue

3

Start / End Page

1650 / 1655

Location

United States

Related Subject Headings

  • Trabecular Meshwork
  • Tonometry, Ocular
  • Tomography, Optical Coherence
  • Singapore
  • Prospective Studies
  • Ophthalmology & Optometry
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Iris
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chong, R. S., Sakata, L. M., Narayanaswamy, A. K., Ho, S.-W., He, M., Baskaran, M., … Aung, T. (2013). Relationship between intraocular pressure and angle configuration: an anterior segment OCT study. Invest Ophthalmol Vis Sci, 54(3), 1650–1655. https://doi.org/10.1167/iovs.12-9986
Chong, Rachel S., Lisandro M. Sakata, Arun K. Narayanaswamy, Sue-Wei Ho, Mingguang He, Mani Baskaran, Tien Yin Wong, Shamira A. Perera, and Tin Aung. “Relationship between intraocular pressure and angle configuration: an anterior segment OCT study.Invest Ophthalmol Vis Sci 54, no. 3 (March 5, 2013): 1650–55. https://doi.org/10.1167/iovs.12-9986.
Chong RS, Sakata LM, Narayanaswamy AK, Ho S-W, He M, Baskaran M, et al. Relationship between intraocular pressure and angle configuration: an anterior segment OCT study. Invest Ophthalmol Vis Sci. 2013 Mar 5;54(3):1650–5.
Chong, Rachel S., et al. “Relationship between intraocular pressure and angle configuration: an anterior segment OCT study.Invest Ophthalmol Vis Sci, vol. 54, no. 3, Mar. 2013, pp. 1650–55. Pubmed, doi:10.1167/iovs.12-9986.
Chong RS, Sakata LM, Narayanaswamy AK, Ho S-W, He M, Baskaran M, Wong TY, Perera SA, Aung T. Relationship between intraocular pressure and angle configuration: an anterior segment OCT study. Invest Ophthalmol Vis Sci. 2013 Mar 5;54(3):1650–1655.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

March 5, 2013

Volume

54

Issue

3

Start / End Page

1650 / 1655

Location

United States

Related Subject Headings

  • Trabecular Meshwork
  • Tonometry, Ocular
  • Tomography, Optical Coherence
  • Singapore
  • Prospective Studies
  • Ophthalmology & Optometry
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Iris